Metals, ceramics, natural or synthetic polymers, and their composites are used as biomaterials aiding the clinician in the repair. Among these, biomaterials in orthopedics have very many demanding characteristics like tunable density, elasticity, and strength near to that of bone, bioresorbability and the ability to bond to live bone and not being toxic to the cells. Hench and Clark paved the way for preparing bioglasses and it is named as 45S5 bioglass. The 45S5 bioglass promotes osteogenesis by