No abstract

Awareness, suspicion of multiple primary malignancy and aggressive diagnostic work up plays crucial role in their detection at earlier stage for better outcome. In addition choice of appropriate chemotherapeutic agents and their regimens remains the cornerstone while managing the patients with multiple primary malignancies.

Breast cancer is the second most common malignancy in Indian women. Basically it is a hormone mediated disorder due to continuous exposure to ovarian hormones. Several established modifiable and non modifiable risk factors influence hormonal status which is associated with breast cancer. Prevalence and profile of risk factors of breast cancer differs region wise. Although etiology of breast cancer is complex and multifactorial involving genetic, hormonaland environmental factors, various studies showed significant role of reproductive risk factors in breast tumor genesis. Present study was aimed to explore association of various hormone related risk factors with breast cancer in Indian women.This hospital based case control study included newly diagnosed cases of breast cancer and age matched healthy women as controls. Standard structured pretested valid questionnaire was administered to record socio demographic data, medical, family, past history, use of hormones and reproductive risk factors. Participants were asked about marital status, number of live births, abortions, age at first live birth and breastfeeding duration history. Information was also obtained regarding age at menarche, menopausal status, age at menopause and use of oral contraceptives and hormone replacement therapy. Anthropometric measures body mass index and waist: hip ratio were taken as index of adiposity. Present study has provided possible association of hormone related risk factors in breast cancer in Indian population.

Introduction: Modified radical mastectomy, the standard surgical procedure in the management of carcinoma of breast is routinely performed under general anesthesia. but the patients of chronic obstructive pulmonary disease with other comorbidites are at increased risk of perioperative morbidity and mortality especially because of pulmonary complications. We report successful perioperative management of modified radical mastectomy only with thoracic epidural

Saree is a common, traditional garment of Indian women, wrapped around the waist is tightened by a thick cord and with one end draped over the shoulder. Tight knot in the same place, sweat, soiling and continuous use can cause pigmentation, scaling of the waist and even transform to malignancy. We present here a case of saree cancer successfully managed with multimodality therapy. A 50-year-old woman was referred to our hospital (India) for itching and non-healing ulcerative lesion on waistline. She was wearing saree continuously for 34 years with knot at the same place. Magnetic resonance images suggested ulcerative growth with lymph node metastasis. She then underwent wide local excision; histopathological examination confirmed it was a squamous cell carcinoma. She therefore received concomitant chemotherapy and radiotherapy. She is now (2 years after the completion of treatment) in remission state. Awareness of saree cancer among Indian is important to avoid malignant lesions at waistline. Multimodality management with surgery, chemotherapy and radiotherapy is ideal mean for good outcome.