No abstract

Anastomotic leakage is still the most undesirable complication of colorectal surgery. The reported incidence of anastomotic leakage after colorectal surgery varies from 1.8% to 15.9%. The impact of anastomotic leakage is increased morbidity, mortality (12–30%), length of stay, and cost of hospitalization; hence, this complication should be prevented as much as possible.Several studies have shown a correlation between low albumin levels and increased anastomotic leakage.The Colon Leakage Score (CLS) is a standard score for predicting anastomotic leakage, but this score does not include the albumin level as a parameter of anastomotic leakage despite the importance of the albumin level’s contribution on the anastomotic leakage. Therefore, this study sought to analyze the correlation between the albumin level, CLS, and the incidence of anastomotic leakage after anastomotic resection surgery in colorectal cancer (CRC) patients at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. This study was a cross-sectional retrospective analytical study on medical records of CRC patients over the age of 18 who underwent intestinal anastomotic resection surgery between 2016–2020. There were thirty-two patients with colorectal cancer underwent anastomotic resection during the study period, with two patients experienced anastomotic leakage. Correlation analysis showed that the correlation coefficient for the albumin level and anastomotic leakage was 0.209, while the correlation coefficient between CLS and anastomotic leakage was 0.110. There is no correlation between albumin level, CLS, and the incidence of anastomotic leakage after anastomotic resection surgery in CRC patients treated at Dr. Hasan Sadikin General Hospital Bandung, Indonesia

Background: Deep vein thrombosis is a blood clot that occurs in the deep veins. Fifty percent of patients with deep vein thrombosis do not show clinical symptoms. The incidence of deep vein thrombosis in colorectal cancer patients is higher than in other cancer patients. Several scoring system models, such as Wells’ criteria and Khorana score, were developed to help diagnose deep vein thrombosis . Methods: This study was a prospective observational analytic with cross sectional design that compared the Khorana score with Wells’ criteria in predicting the occurrrence of asymptomatic deep vein thrombosis in colorectal cancer patients. Comparisons were made using Chi Square analytical test and diagnostic tests. Results: A total of 63 patients were obtained. Using Wells’ criteria, 55 patients (87.3%) fell into the mild risk category, 8 patients (12.7%) in the moderate risk category and no patients in the high risk category. Using Khorana score, 35 patients (55.6%) fell into the mild risk category, 28 (44.4%) patients in the moderate risk category, and no high risk category patients were found. There were 14 patients (22.2%) with asymptomatic deep vein thrombosis and 49 patients (77.8%) without deep vein thrombosis. Comparison of the proportion of Wells’ criteria with asymptomatic patients has a p-value of 0.48, while Khorana score with asymptomatic patients has a p-value of 0.001. Conclusion: Khorana score is better than Wells’ criteria in detecting asymptomatic deep vein thrombosis in colorectal cancer patients.

Latar Belakang: Efusi pleura maligna (EPM) adalah salah satu bentuk infiltrasi dan metastasis suatu kanker. Adanya EPM menunjukkan penyakit keganasan sudah berada pada tahap lanjut. Hal ini akan mempengaruhi kualitas hidup pasien serta mengindikasikan angka harapan hidup rendah. Dengan angka harapan hidup yang berkisar antara beberapa hari hingga 12 bulan, pasien kanker stadium lanjut akan menderita dari segi fisik, psikososial, dan spiritual, karenanya pengobatan bersifat paliatif dan fokus pada perbaikan kualitas hidup. Tatalaksana pasien dengan EPM adalah melakukan drainase cairan pleura, yang dapat dilakukan dengan chest tube thoracostomy (CTT) atau torakosintesis. Beberapa faktor dipercaya berpengaruh pada tingkat mortalitas pasien dengan EPM yang dilakukan CTT. Penelitian ini untuk mengetahui faktor- faktor prediktor mortalitas 30 hari pasien dengan EPM yang dilakukan CTT. Metode: Penelitian ini adalah studi kohort prospektif terhadap pasien EPM dan dilakukan CTT di RSUP Dr. Hasan Sadikin (RSHS) selama periode Desember 2017 – April 2018. Dilihat asal tumor, leukositosis, anemia, hipoprotein cairan pleura, kadar pH cairan pleura, skor performa ECOG, dan asidosis respiratorik, kemudian pasien di observasi selama 30 hari. Selanjutnya dilakukan uji statistik bivariat dengan uji Chi-Square dan Fisher, kemudian dilakukan uji statistik multivariat dengan menggunakan regresi logistik. Hasil: Terdapat 34 pasien EPM yang memenuhi syarat penelitian, mayoritas pasien hidup, yaitu sebanyak 23 pasien (67,6%). Rata-rata usia pasien yang hidup adalah 48,09 ± 16,209 tahun, sedangkan yang meninggal adalah 42,18 ± 18,110 tahun. Rata-rata lama rawat pasien yang hidup adalah 31,70 ± 11,392 hari, sedangkan yang meninggal adalah 6,64 ± 4,154 hari. Pada pasien EPM yang meninggal didapatkan beberapa faktor yang memiliki hubungan bermakna dengan angka mortalitas, yaitu asal tumor (p = 0,044), leukositosis (p = 0,039), anemia (p = 0,039), hipoprotein cairan pleura (p < 0,01), kadar pH cairan pleura (p < 0,01), dan skor performa ECOG (p < 0,01), sedangkan asidosis respiratorik tidak memiliki hubungan yang bermakna terhadap angka mortalitas (p = 0,549). Simpulan: Asal tumor, leukositosis, anemia, hipoprotein cairan pleura, kadar pH cairan pleura dan skor performa ECOG dapat dijadikan sebagai prediktor mortalitas 30 hari pada pasien dengan EPM yang dilakukan CTT.