The aim of this study was to evaluate burn wound healing activity of coconut shell liquid smoke (CS-LS) in a burn wound animal model. Burn wound–induced mice were treated with CS-LS (CS-LS group), povidone iodine 10% (povidone group), or NaCl 0.9% (NaCl group). Application of CS-LS promoted wound contraction compared to that of the povidone and NaCl groups (P < .05). This study showed a positive correlation between the number of fibroblasts and wound contraction. The number of fibroblasts was highest in the CS-LS group, compared to that of the povidone and NaCl groups (P < .05). In conclusion, CS-LS promotes burn wound healing by one possible mechanism, by increasing the number of fibroblasts. The results indicate that further experimental trials are needed to develop CS-LS as an alternative topical drug for burn wound healing.

No abstract

Reactive oxygen species (ROS) are oxygen derivatives that arise intrinsically from the oxidative phosphorylation process and extrinsically as a response to xenobiotics and pollution. ROS is involved in various conditions such as exercise, aging, inflammation, and neurodegenerative diseases. In the aging process, increased cellular senescence and decreased endogenous antioxidants also occur. Meanwhile, physical activity, specifically exercise, can modulate ROS. The impact of exercise on ROS varies from harmful to beneficial and depends on the type of exercise as they induce different types of ROS. Long-term exercise regulates signaling pathways that enhance antioxidant defense systems and control ROS production. This review will discuss studies on how exercise can regulate ROS and which type of exercise has a role in delaying the aging process. This review also exposes the impact of nutraceutical antioxidant agents that likely enhance the benefit of exercise. The nutraceutical antioxidants agents that likely enhance the benefit of exercise are creatine, whey, and ascorbic acid. Exercise is rewarding for the aging population concerning increasing their quality of life. Special consideration to exercise needs to be given to the type of exercise, and the exercise must be done continuously.

Workers of PT. Grandtex is divided into three different divisions; nonproduction division, weaving division, and spinning division. These workers have different activities, job processes, and work environments, especially in the cotton dust exposure rate. Exposure to cotton dust can influence physical working capacity. This study aimed to find out physical working capacity differences between workers of nonproduction division, weaving division, and spinning division. A comparative analytic survey study is conducted on 112 subjects, which consists of 32 nonproduction division workers, 40 weaving division workers, and 40 spinning division workers. Subjects are picked by the stratified random sampling method. Physical working capacity measured by using an anaerobic capacity parameter (V̇O2 max)with the Astrand-Rhyming chair test. The homogeneity of the result is tested by the Levene test and the normality is tested by Kolmogorov-Smirnov. To find out the differences, those data are analyzed by one-way ANOVA test (p<0,05) and followed by Duncan test to measure how big the differences are. The result of data analyzed with ANOVA indicated that there is a significant difference in physical working capacity (V̇O2 max)(p=0,000) among workers of nonproduction, weaving, and spinning division. This result was also followed by Duncan’s test suggesting thatthe physical working capacity (V̇O2 max) of nonproduction workers are bigger than weaving production workers and also bigger than spinning workers (35,78 ± 7,27 vs 31,50 ± 7,59 vs 28,03 ± 5,92 ml/kg BW/minute). From this study, we can conclude that the physical working capacity (V̇O2 max) of nonproduction workers is better than weaving and spinning division workers.