Menstrual disturbance in adolescense often related with reproductive health problem. Nearly 75% of adolescents experience menstrual-related disorders such as irregular menstrual cycles. This study aims to analyze the factors that affect the regularity of the menstrual cycle in adolescent girls, including body mass index, hemoglobin levels, physical activity, stress levels, and age of menarche. This research is a correlational analytic study with a cross sectional approach. A total of 65 young women became respondents in this study, which were determined using stratified simple random sampling technique. The data collection tools used were questionnaires, weight scales, height gauges and HBmeter. Data were analyzed using descriptive and correlational statistics with a confidence level of 95%. Based on the results of data analysis, it was found that in general the majority of respondents had a normal BMI (50.8%), 18 years old (60%), low Hb (52.3%), light physical activity (50.8%), stress levels. moderate (44.6%), and the age of menarche was at the age of 13 years (36.9%). The results of the correlation analysis showed that the relationship between body mass index, hemoglobin levels, physical activity, stress levels, and age of menarche was respectively (p = 0.219; r - 0.155, p = 0.007; r = -0.330, p = 0.047 ; r = -0.232, p = 0.005; r = 0.334, p = 0.696; r = -0.044). There is a relationship between Hb levels, physical activity and stress levels on menstrual cycle regularity. There is no relationship between BMI and age of menarche with menstrual cycle regularity in adolescent girls.