Demam tifoid atau yang dikenal dengan demam enterik merupakan penyakit infeksi sistemik yang berpotensi fatal yang disebabkan oleh bakteri Salmonella enterica typhi (S.typhy). Pada daerah endemik, sekitar 90% dari demam enterik adalah demam tifoid. Indonesia memilki insiden yang cukup tinggi dengan jumlah kasus yang terus meningkat. Diperkirakan mortalitas dari kasus demam tifoid di Indonesia antara 0,6% sampai 2%. Antibiotika merupakan terapi utama untuk penanganan pasien demam tifoid. Tujuan penelitian ini adalah untuk mengetahui pola penggunaan antibiotika pada dewasa dengan demam tifoid di RSUP Sanglah Denpasar tahun 2016-2017. Jenis penelitian yang digunakan adalah observasional dengan metode cross-sectional. Pengambilan data dilakukan secara retrospektif. Sampel diambil dari rekam medis pasien dewasa dengan demam tifoid yang dirawat di RSUP Sanglah Denpasar tahun 2016-2017. Teknik pemilihan subjek menggunakan total sampling. Subjek merupakan pasien dewasa dengan demam tifoid yang dirawat di RSUP Sanglah Denpasar. Total sampel yang diperoleh sebanyak 55 pasien dewasa dengan demam tifoid. Golongan antibiotika yang digunakan di RSUP Sanglah adalah ampisilin, sefalosporin generasi ketiga, fluorokuinolon, dan azitromisin. Jenis antibiotika yang digunakan seperti ampisilin, seftriakson, sefiksim, levofloxacin, dan azitromisin. Dapat disimpulkan bahwa antibiotika yang digunakan di RSUP Sanglah Denpasar adalah jenis levofloxacin (45,5%) dari golongan fluorokuinolon dengan rute pemberian di rumah sakit secara intravena dan diberikan selama 3-7 hari. Kata kunci : Demam tifoid, Antibiotika, RSUP
Introduction: Acute generalized exanthematous pustulosis (AGEP) is a severe allergic skin reaction associated with substance use. Not all drugs cause an AGEP reaction. The incidence of AGEP is extremely rare compared to other drug allergies. Therefore, correct identification and proper history acquisition are important for the purpose of providing appropriate and prompt treatment to patients, improving good prognosis and reducing mortality. Case Presentation: A 17 years antique male affected person, got here with leader proceedings of purple spots at the palms and ft observed with the aid of using itching. Red spots seem after the affected person takes the drug. The affected person became given remedy withinside the shape of oral antihistamines, intravenous steroids, and topical steroids. The affected person became discharged from the health center in excellent condition. Conclusion: Acute Generalized Exanthematous Pustulosis is a skin disorder that is generally caused by drugs and has a good prognosis because it can heal by itself. Key words: acute generalized exanthematous pustulosis, drug eruption, skin, disease.
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