China is socialist country,has the largest population in the world and the largest number of children in the world. As a socialist country, China has made many contributions to children's health care, especially children's school health, since liberation, great changes have taken place, and the government has invested a lot! This article reviews the government's investment, work and achievements in school health since China's liberation.The above all lead to physical health problems of a variety of reasons, on the whole, a society that during the rapid development and changing, some of the reasones is the inevitable. Outcome of the modern can't deserve it, such as living environment, transportation, family structure, such as cannot be restored to its previous state, but there are many reasons can be through the efforts of the society and human oneself to control or eliminate, such as unreasonable diet, unhealthy habits overweight study pressure, improper physical education, etc. In fact, of course, closely rely on the educational intervention is not enough, because the cause of adolescent physical health problems, its formation is a complex social background, has a long history, has a profound historical and cultural origins, some concomitant with the modernization, is facing the rapid advance of modernization, the entire Chinese society off guard, don't have enough ideas and material preparation. Therefore, to solve the current adolescent health problems is a long-term and difficult, we must mobilize the whole society to work together as a systematic project.
Background: Many cytokines play essential roles in the occurrence and development of acute graft-versus-host-disease (aGVHD). This study aims to validate whether 11 proinflammatory and anti-inflammatory cytokines can be a candidate for aGVHD biomarkers to predict its occurrence and outcome. Methods: Out of 178 patients who underwent allogeneic hematopoietic stem cell transplantation, we retrospectively enrolled 32 cases into the pre-transplant cohort and 45 cases into the post-transplant cohort. The serum cytokine concentrations were determined by flow cytometry. The control and experimental groups were non-aGVHD, I-II aGVHD and III-IV aGVHD groups, respectively. Risk factors and overall survival (OS) were also evaluated. Results: In the pre-transplant cohort, interleukin (IL)-2 decreased in patients with aGVHD, and IL-4 only reduced in patients with III-IV aGVHD. In the post-transplant cohort, only IL-4 increased 1.79 times more in patients with III-IV aGVHD than in the other two groups. Patients with gastrointestinal (GI) aGVHD had lower IL-2, IL-4 and IL-17F levels pre-transplant and lower IL-2 post-transplant. None of the other cytokines was significantly different. Logistic regression analysis showed that no cytokine could predict the occurrence and outcome of aGVHD. Diarrhea within 15 days post-transplant is an independent risk factor for the occurrence of aGVHD and a risk factor for a fatal outcome. Patients without diarrhea had longer survival time of 672 (586-757) days vs 444 (229-548) days and better 2-year OS (85.7% vs 46.4%) than those with diarrhea. Compared to patients with aGVHD, patients without aGVHD had a longer survival time of 618 (530-706) days vs 449 (353-545) days and better 2-year OS (76.2% vs 47.1%). Conclusions: Proinflammatory and anti-inflammatory cytokines can provide specific indications for the occurrence and progression of aGVHD. However, to truly guide the diagnosis and prognosis, cytokines with larger sample sizes, more detection time points and more accurate diagnostic efficacy need to be further studied.
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