Controlling the formation of longitudinal cracks on hypo-peritectic steel slab surfaces is one of the key challenges in continuous casting worldwide. Based on the production in Chongqing Iron & Steel Co., mould fluxes with high basicity ranging from 1.7 to 1.8 were put forward and the effects of compositions on the basic properties of mould flux were studied in the present paper.After laboratory experiments, a high-basicity mould flux with an increased crystallisation speed to abate the heat-transfer capability in the meniscus area was fully applied in the first steelmaking plant of Chongqing Iron & Steel Co. Using the high-basicity mould flux, for more than 3 million tonnes of slab production, the large longitudinal crack was eliminated and the rate of formation of small longitudinal cracks decreased greatly. During the production process, sticking that impedes the smooth running of continuous casting was infrequent, and the spot check for longitudinal cracks on micro alloy steel surface was simplified in the slab finishing process. Furthermore, since the application effect of mass production is remarkable, the hot charging process is better implemented, and the contract can be accomplished in time. In summary, the problem of longitudinal cracks on hypo-peritectic steel slab surfaces is finally resolved and the high-basicity mould fluxes have become indispensable auxiliary materials during continuous casting of hypo-peritectic steel.