Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.

A novel fungal metabolite, arthrinone [1], was isolated from the culture broth oí Arthrinium sp. FA 1744 by chromatographic methods. The structure and relative stereochemistry of arthrinone were determined by spectral and single-crystal X-ray analyses.

No abstract

In this paper the average run length is adopted as the tool to describe the performance of control charts. The respective methods for calculating the average run length of the modified Shewhart control chart and the Shewhart residual control chart for 2-order autoregressive process are derived and shown in detail. By the proposed approach some numerical results of average run lengths of both Shewhart type charts are formulated and discussed. We analyze and compare that the influence of the correlation coefficients of the 2-order autoregressive process on the performance of both charts based on the estimated data. Several clear and main points of the issue are summed up. Lastly, we give some recommendations for the choice of both Shewhart type control schemes.