Purpose User-generated content on social media sites, such as health-related online forums, offers researchers a tantalizing amount of information, but concerns regarding scientific application of such data remain. This paper compares and contrasts symptom cluster patterns derived from messages on a breast cancer forum with those from a symptom checklist completed by breast cancer survivors participating in a research study. Methods Over 50,000 messages generated by 12,991 users of the breast cancer forum on MedHelp.org were transformed into a standard form and examined for the co-occurrence of 25 symptoms. The k-medoid clustering method was used to determine appropriate placement of symptoms within clusters. Findings were compared with a similar analysis of a symptom checklist administered to 653 breast cancer survivors participating in a research study. Results The following clusters were identified using forum data: menopausal/psychological, pain/fatigue, gastrointestinal, and miscellaneous. Study data generated the clusters: menopausal, pain, fatigue/sleep/gastrointestinal, psychological, and increased weight/appetite. Although the clusters are somewhat different, many symptoms that clustered together in the social media analysis remained together in the analysis of the study participants. Density of connections between symptoms, as reflected by rates of co-occurrence and similarity, was higher in the study data. Conclusions The copious amount of data generated by social media outlets can augment findings from traditional data sources. When different sources of information are combined, areas of overlap and discrepancy can be detected, perhaps giving researchers a more accurate picture of reality. However, data derived from social media must be used carefully and with understanding of its limitations.

Using visual analytic systems effectively may incur a steep learning curve for users, especially for those who have little prior knowledge of either using the tool or accomplishing analytic tasks. How do users deal with a steep learning curve over time? Are there particularly problematic aspects of an analytic process? In this article we investigate these questions through an integrative study of the use of CiteSpace—a visual analytic tool for finding trends and patterns in scientific literature. In particular, we analyze millions of interactive events in logs generated by users worldwide over a 14‐month period. The key findings are: (i) three levels of proficiency are identified, namely, level 1: low proficiency, level 2: intermediate proficiency, and level 3: high proficiency, and (ii) behavioral patterns at level 3 are resulted from a more engaging interaction with the system, involving a wider variety of events and being characterized by longer state transition paths, whereas behavioral patterns at levels 1 and 2 seem to focus on learning how to use the tool. This study contributes to the development and evaluation of visual analytic systems in realistic settings and provides a valuable addition to the study of interactive visual analytic processes.

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BackgroundEssential proteins are indispensable to the survival and development process of living organisms. To understand the functional mechanisms of essential proteins, which can be applied to the analysis of disease and design of drugs, it is important to identify essential proteins from a set of proteins first. As traditional experimental methods designed to test out essential proteins are usually expensive and laborious, computational methods, which utilize biological and topological features of proteins, have attracted more attention in recent years. Protein-protein interaction networks, together with other biological data, have been explored to improve the performance of essential protein prediction.ResultsThe proposed method SCP is evaluated on Saccharomyces cerevisiae datasets and compared with five other methods. The results show that our method SCP outperforms the other five methods in terms of accuracy of essential protein prediction.ConclusionsIn this paper, we propose a novel algorithm named SCP, which combines the ranking by a modified PageRank algorithm based on subcellular compartments information, with the ranking by Pearson correlation coefficient (PCC) calculated from gene expression data. Experiments show that subcellular localization information is promising in boosting essential protein prediction.

In this paper, we introduce attribute-aware fashionediting, a novel task, to the fashion domain. We re-define the overall objectives in AttGAN [5] and propose the Fashion-AttGAN model for this new task. A dataset is constructed for this task with 14,221 and 22 attributes, which has been made publically available. Experimental results show effectiveness of our Fashion-AttGAN on fashion editing over the original AttGAN.