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The assessment of settlement deformation of engineered structures under high-speed railway tracks is an important control link in high-speed railway line construction. This paper discusses characteristics of settlement deformation of sections of subgrade, bridges and tunnels, and analyzes the suitability of predictive methods in currently available technical codes and standards based on measured data of settlement deformation. Currently available assessment analysis methods have good applicability for subgrade sections but are not suitable for sections of bridges and tunnels. Suitable assessment analysis methods are proposed and have been successfully applied to settlement deformation of engineered structures under the tracks of high-speed railway lines. The methods suit the characteristics of “small magnitude and large fluctuation” changes of measured settlement deformations taking account of the construction process of the engineered project.