In order to represent the mechanical response laws of high-modulus asphalt pavement (HMAP) faithfully and objectively, the viscoelasticity of high-modulus asphalt mixture (HMAM) was considered, and the viscoelastic mechanical responses were calculated systematically based on moving load by numerical simulations. The performances of the HMAP in resistance to the deformation and the cracking at the bottom layer were compared with the ordinary asphalt pavement. Firstly, Lubao and Honeywell 7686 (H7686) were selected as the high modulus modifiers. The laboratory investigations of Asphalt mix-70 penetration, Asphalt mix-SBS (styrene-butadiene-styrene), HMAM-Lubao and HMAM-H7686 were carried out by dynamic modulus tests and wheel tracking tests. The conventional performances related to the purpose of using the HMAM were indicated. The master curves of the storage moduli were obtained and the viscoelastic parameters were fitted based on viscoelastic theories. Secondly, 3D pavement models based on moving loads for the viscoelastic structures were built using the non-linear finite element software ABAQUS. The wheel path was discretized in time and space to apply the Haversine wave load, and then the mechanical responses of four kinds of asphalt pavement were calculated. Finally, the sensitivity analysis was carried out. The results showed that the addition of the high modulus modifiers can improve the resistance to high-temperature rutting of the pavements. Except for the tensile strain and stress at the bottom of the underlayer, other responses decreased with the increases of the dynamic moduli and the change laws of the tensile strain and stress were affected by the range of the dynamic modulus. The tensile stress at the bottom of the asphalt layer would be too large if the modulus of the layer were too large, and a larger tensile strain would result. Therefore, the range of the modulus must be restricted to avoid the cracking due to excessive tension when using the HMAM. The resistance of the HMAP to deformation was better and the HMAP was less sensitive to load changes and could better withstand the adverse effects inflicted by heavy loads.

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Accumulating evidence indicates that the dysregulation of circular RNAs (circRNAs) contributes to tumor progression; however, the regulatory functions of circRNAs in renal cell carcinoma (RCC) remain largely unknown. In this study, the function and underlying mechanism of circAMOTL1L in RCC progression were explored. qRT-PCR showed the downregulation of circAMOTL1L in RCC tissues and cell lines. The decrease in circAMOTL1L expression correlated with the tumor stage, metastasis, and poor prognosis in patients with RCC. Functional experiments revealed that circAMOTL1L inhibited cell proliferation and increased apoptosis in RCC cells. Subcutaneous implantation with circAMOTL1L-overexpressing cells in nude mice decreased the growth ability of the xenograft tumors. Mechanistically, circAMOTL1L served as a sponge for miR-92a-2-5p in upregulating KLLN (killin, p53-regulated DNA replication inhibitor) expression validated by bioinformatics analysis, oligo pull-down, and luciferase assays. Further, reinforcing the circAMOTL1L–miR-92a-2-5p–KLLN axis greatly reduced the growth of RCC in vivo. Conclusively, our findings demonstrate that circAMOTL1L has an antioncogenic role in RCC growth by modulating the miR-92a-2-5p–KLLN pathway. Thus, targeting the novel circAMOTL1L–miR-92a-2-5p–KLLN regulatory axis might provide a therapeutic strategy for RCC.

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Abstract-In this paper, for the problem of the security of students in primary and secondary schools, we propose a campus intelligent safety supervision system based on RFID technology. Through the use of RFID technology for non-contact automatic recognition features, the system achieves the goal of supervising the school gate, classroom, danger zone entrance and other places in the primary and secondary schools. Then the information of the acquisition is classified, compared, displayed, alarm, etc. The information is automatically acquired and transmitted in real time, which makes the supervision and management of the school more intelligent. Compared with the existing campus management system, the system can be more accurate access to information in real-time, improve the convenience and effectiveness of safety management, and realize the intelligent supervision and management of the students in primary and secondary schools.Keywords!RFID, smart. Safety, supervision system IntroductionAt present, the application of contact smart card in the campus management is quite mature. In general, people offer for operation with card, but if there are more people to waiting in line, the process will waste a lot of time, and information identification is relatively slow [1]. Students usually need to get the attendance information by name. If there are more students in the class, the attendance takes up a lot of class times between teachers and students. In addition, the teaching attendance of teacher is basically carried out by inspection of school administrators, which result in the waste of manpower. Contact smart card can not timely obtain the distribution of students on campus, and also not avoid some incidents, such as fighting, skipping class. etc. Therefore, a smart campus safety supervision system based on RFID technology is proposed to supervise the all situation [2,3].With the rapid development of hardware and software technology and the strong support of national policies, Harry K. H. Chow etc. studied the application of RFID in logistics management and transportation [4,5], which not only facilitates the management of goods, but also saves a lot of manpower. Luo chunbin and Yi Bin analyzed the applications and advantages of RFID in traffic and anti-counterfeiting [6]. In 152