The early rebleeding rate after EVL is mainly affected by the volume of ascites, number of rubber bands used to ligate, severity of varices and prolonged PT. Effective measures for prevention and treatment should be adopted before and after EVL.
FAT10 may be involved in gastric carcinogenesis, and is a potential marker for the prognosis of gastric cancer patients. FAT10 and mutant p53 may play a common role in the carcinogenesis of gastric cancer.
INTRODUCTION:Accurate identification of early gastric cancer (EGC) differentiation status and margins is critical for determining the surgical strategy and achieving curative resection in EGC patients. The aim of this study was to develop a real-time system for accurately identifying differentiation status and delineating margins of EGC in Magnifying Narrow-band Imaging (ME-NBI) endoscopy.
METHODS:2217 images from 145 EGC patients and 1870 images from 139 EGC patients were retrospectively collected to train and test the convolutional neural network (CNN) 1 for identifying EGC differentiation status. 882 images from 58 EGC patients were used to compare the performance of CNN1 with that of experts. 928 images from 132 EGC patients and 742 images from 87 EGC patients were used to train and test CNN2 for delineating EGC margins.
RESULTS:The system correctly predicted differentiation status of EGCs with an accuracy of 83.3% (95%CI: [81.5%-84.9%]) in testing dataset. In the man-machine contest, CNN1 performed significantly better compared to the five experts [86.2% (95%CI: [75.1%-92.8%]) vs. 69.66 (95%CI: [64.1%-74.7%])). For delineating EGC margins, the system achieved an accuracy of 82.7% (95%CI: [78.6%-86.1%]) in differentiated EGC and 88.1% (95%CI: [84.2%-91.1%]) in undifferentiated EGC under an overlap ratio of 0.80. In unprocessed EGD videos, the system achieved real-time EGC differentiation status diagnosis and EGC margin delineation in ME-NBI endoscopy.
CONCLUSION:We developed a deep learning-based system for accurately identifying differentiation status and delineating margins of EGC in ME-NBI endoscopy. This system achieved a superior performance when compared with experts, and was successfully tested in real EGC videos.
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