Background:The generation of catalytic antibodies (abzymes) by the anti-idiotypic antibody approach was hampered by their incompatible CDR structure with the active site of the enzyme. Results: The high incidence of anti-idiotypic abzymes with alliinase activities was produced by the anti-idiotypic nanobody approach. Conclusion:The anti-idiotypic nanobodies are efficient natural enzyme mimics. Significance: This study provided a new approach for producing abzymes that could be broadly applied to antibody-catalyzed prodrug activation.

No abstract

No abstract

No abstract