No abstract

Adenoid hypertrophy (AH) is an obstructive condition due to enlarged adenoids, causing mouth breathing, nasal blockage, snoring and/or restless sleep. While reliable diagnostic techniques, such as lateral soft tissue x-ray imaging or flexible nasopharyngoscopy, have been widely adopted in general practice, the actual impact of airway obstruction on nasal airflow and inhalation exposure to drug aerosols remains largely unknown. In this study, the effects of adenoid hypertrophy on airflow and micron particle inhalation exposure characteristics were analysed by virtually comparing pre- and postoperative models based on a realistic 3-year-old nasal airway with AH. More specifically, detailed comparison focused on anatomical shape variations, overall airflow and olfactory ventilation, associated particle deposition in overall and local regions were conducted. Our results indicate that the enlarged adenoid tissue can significantly alter the airflow fields. By virtually removing the enlarged tissue and restoring the airway, peak velocity and wall shear stress were restored, and olfactory ventilation was considerably improved (with a 16∼63% improvement in terms of local ventilation speed). Furthermore, particle deposition results revealed that nasal airway with AH exhibits higher particle filtration tendency with densely packed deposition hot spots being observed along the floor region and enlarged adenoid tissue area. While for the postoperative model, the deposition curve was shifted to the right. The local deposition efficiency results demonstrated that more particles with larger inertia can be delivered to the targeted affected area following Adenoidectomy (Adenoid Removal). Research findings are expected to provide scientific evidence for adenoidectomy planning and aerosol therapy following Adenoidectomy, which can substantially improve present clinical treatment outcomes.

Although many parametric studies have been conducted in developing standardized nasal geometry and analysing associated airflow dynamics, most of them are based on symmetrical nasal chambers assumption, while the inter-chamber variations due to the morphological asymmetry of the two nasal chambers are much less investigated. To address this issue, this paper presents an inter-chamber anatomical variability study by developing a shape comparison method to quantify inter-chamber anatomical differences. Then the anatomical deviation is correlated with the flow apportionment and the associated nanoparticle deposition patterns using CFD method. Results show that noticeable inter-chamber difference is observed especially in the inferior and middle passages where most inhaled flow is distributed to. Additionally, the shape of vestibule notch and septum deviation contributes to the discrepancy flow behaviour between two chambers. Consequently, these differences lead to variations in regional nanoparticle deposition, especially for 1 nm particles in the olfactory region, where the inter-chamber differences can reach up to 400%. Our results suggest that the inter-chamber anatomical variation should be considered when developing standardized nasal models.