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ObjectivesElder self‐neglect is a global public health problem, and older people admitted to the hospital may have a higher risk of self‐neglect due to their deteriorating health conditions. This study aimed to translate, adapt and validate the Abrams geriatric self‐neglect assessment scale (AGSS) among older Chinese people admitted to the hospital.MethodsData were derived from a cross‐sectional survey of a convenience sample of 452 older people admitted to a general hospital. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to examine the structural validity of the AGSS. Content validity, criterion validity, internal consistency reliability, and test–retest reliability were also conducted to assess the psychometric properties of the scale.ResultsEFA yielded a 6‐item one‐factor model, which was supported by CFA and explained 44.74% of the total variance. The internal consistency was acceptable (Cronbach α = 0.740), and the test–retest reliability with a 14‐day interval was good (intraclass correlation coefficient, ICC = 0.966). Significantly positive correlations with the caregiver‐rated elder self‐neglect assessment scale (r = 0.648) supported the concurrent validity of the scale. Significant differences in scores between respondents with different ages, marital statuses, educational levels and numbers of chronic diseases demonstrated the discriminative validity.ConclusionThe Chinese version of the AGSS is an easy‐to‐use, reliable and valid measure with satisfactory psychometric properties. Future studies should recruit a more representative sample of older people in China to verify the applicability of the scale.Implications for PracticeThe Chinese version of the AGSS enables clinical staff to accurately screen for and assess elder self‐neglect upon hospital admission, which can inform the development of specific interventions and assignment of additional guardianship to those at risk of elder self‐neglect.

Trichloroethylene (TCE) is a metal detergent commonly used in industry that can enter the human body through the respiratory tract and skin, causing occupational medicamentosa-like dermatitis due to TCE (OMDT) and multiple organ damage, including liver failure. However, the pathogenesis of liver injury remains unclear. Kupffer cells (KCs) are important tissue macrophages in the body because the polarization of KCs plays a crucial role in immune-mediated liver injury. However, the mechanism of KCs polarization in TCE-induced immune liver injury has not been thoroughly elucidated. In this study, we investigated the effect of TCE-induced KCs polarization on liver function and signal transduction pathways using the TCE sensitization model developed by our group. BALB/c mouse skin was exposed to TCE for sensitization, and an increase in the expression of M1 macrophage-specific markers (CD16/CD32, iNOS), M1 macrophage-specific cytokines IL-1β, and IFN-γ, P-JAK-1 and P-STAT1 levels were also found to be dramatically increased. When using low doses of gadolinium trichloride (GdCl3), the expression of these proteins and mRNA was significantly reduced. This phenomenon indicates that GdCl3 blocks TCE-induced polarization of KCs and suggests that the IFN-γ/STAT1 signaling pathway may be involved in the polarization process of KCs. These findings clarify the relationship between the polarization of KCs and immune liver injury and highlight the importance of further study of immune-mediated liver injury in TCE-sensitized mice.