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The non-invasive approach for early cancer detection promises a screening assay accessible for everyone. However, the delivery of this promise is limited due mostly to the high sequencing cost associated with available assays. Here, we developed a multimodal assay called SPOT-MAS (Screening for the Presence Of Tumor by Methylation And Size) to simultaneously profile methylomics, fragmentomics, copy number, and end motifs in a single workflow using targeted and shallow genome-wide sequencing of cell-free DNA. We applied SPOT-MAS to 738 nonmetastatic patients with breast, colorectal, gastric, lung and liver cancer, and 1,550 healthy controls. SPOT-MAS detected the five cancer types with a sensitivity of 72.4% and specificity of 97.0%, with AUC of 0.95 (95% CI 0.93-0.96). For tumor-of-origin, a graph convolutional neural network was adopted and could achieve an accuracy of 0.7. In conclusion, our study demonstrates comparable performance to other early cancer detection assays while requiring significantly lower sequencing depth, making it economically feasible for population-wide screening.

In this paper, we introduce a new non-Gaussian state called superposition of photon-added pair coherent state (SPAPCS) by superposition addition of photons to two modes of a pair coherent state (PCS). It is demonstrated that the SPAPCS has an enhanced non-Gaussian property by testing its Wigner function when increasing the number of photons added to two modes of the PCS. We use the field as a SPAPCS to study a dynamical entanglement in a dispersive two-mode Jaynes–Cummings model in dissipation atom-field interaction. We detect the dynamical entanglement degrees of the global system and subsystems by using the linear entropy criteria. The obtained results show the dynamical entanglement degrees can be enhanced by the phase damping effect as well as the superposition adding photons to two modes of the field in SPAPCS.

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In this paper, we study some higher-order nonclassical properties of the superposition of three-mode photon-added trio coherent state such as antibunching, squeezing, and entanglement. The results show that in the case with fixed the higher-order, when increasing the numbers of added photons, the manifestation of the higher-order three-mode sum squeezing is more obvious, but the degrees of higher-order antibunching, and higher-order three-mode entanglement are more reduced. Besides, with fixed the numbers of photon addition to the superposition of three-mode photon-added trio coherent state, the higher-order nonclassical properties as antibunching and entanglement are more pronounced, but three-mode sum squeezing is more decreased when increasing the number of the higher-order.