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A new method to evaluate patients with equivocal obstruction of the pelvioureteral junction is described. It involves the performance of a standard 131iodine-hippuran renogram followed by a second renogram 3 minutes after an intravenous injection of the diuretic, frusemide. When the 2 results are inspected together it is found that the patients can be separated into 4 groups: 1) normal, 2) obstructed, 3) atonic and 4) partially obstructed. The results in 23 children and 27 adults with suspected obstruction of the pelvioureteral junction are presented. Obstruction was confirmed in 18 patients and excluded in 32. The correlation between the renogram results and clinical, radiological and operative findings is discussed. The technique is simple, accurate and non-invasive, and it is recommended after excretory urography before proceeding to more invasive tests.

Technegas and Pertechnegas are radioactive aerosols produced in a commercial generator and used for lung scintigraphy. The aerosols are produced by first evaporating to dryness standard technetium-99m generator eluate (99mTcO4 in normal saline) in a graphite crucible (the simmer stage) and then heating this to 2500 degrees C (the "burn" stage). The aim of this work was to measure the particle size distributions of these agents and relate this to regional lung deposition. Factors that may vary during production of the aerosol in routine use were investigated to determine whether they influenced the particle size. Activity size distributions were measured using a serial wire-screen diffusion battery. The Technegas size distribution was approximately log-normal with an activity median diameter of 158 nm and a geometric standard deviation of 1.5. The results for Pertechnegas were similar. The median size increased with the number of simmers and with the time from generation. The increase in size with the number of simmers is thought to be due to the increased salt content in the crucible prior to the "burn". The predicted lung deposition is 37% in the alveolar region and 5% in the bronchial region. Significant changes in deposition are not predicted over the range of particle sizes measured.

Krypton-81m gas, by virtue of its imaging characteristics, is often considered the "gold standard" for ventilation scintigraphy but its use is restricted by its high cost and limited availability. The new radiopharmaceutical 99Tcm-Technegas, a suspension of ultrafine technetium-99m labelled carbon particles, produces high-quality images of ventilation and has the advantage of continuous availability. As part of our evaluation of Technegas the two were compared in 40 patients with a variety of established respiratory diseases. Disparities were seen in five patients in five diagnostic groups and may be a consequence of the differing physical properties of the two agents and the different inhalation techniques used. In addition two interesting features were noted on the Technegas images. (1) Hot spots were seen in 50% of patients, particularly in those with a degree of airways obstruction; (2) preferential basal deposition of activity was seen in 30%, particularly in patients with idiopathic pulmonary fibrosis. Both features were significantly associated with parameters of pulmonary function indicating obstructive lung disease in the former case and restrictive lung disease in the latter.

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