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Objective:The purpose of this study was to evaluate the anti-diabetic activity of ethanol extract of Tabernamontana divaricata (L.) and its ameliorative effect on oxidative stress in alloxan-induced diabetic rats.Materials and Methods:Diabetes was induced by single intraperitoneal injection of alloxan monohydrate (140 mg/kg body weight). Methanol extract of T. divaricata was administered at the doses of 100 and 200 mg/kg body weight in diabetic induced rats including glibenclamide (3 mg/kg) as a reference drug. In the continuous 21 days treatment, fasting blood glucose level was determined on 0, 7, 14 and 21 days. On day 21, serum lipid profiles and glycosylated hemoglobin, liver antioxidant enzymes levels were estimated.Results:Experimental findings showed a significant anti-diabetic potential of the extract in terms of reduction in blood glucose levels and a correct effect on the altered biochemical parameters. Observed data were found statistically significant in correction of antioxidant enzyme level accompanied with diabetes, particularly at the dose of 200 mg/kg body weight.Conclusion:Based on the results, it can be concluded that the T. divaricata is found to be effective in type 2 diabetes in rats and to have an ameliorative effect on the associated oxidative stress.

Many elderly people today suffer from disease and health issues. One of the most difficult is Parkinson's disease, which is caused by the death of dopamine cells in the midbrain. Among other symptoms, Parkinson's patients usually suffer from difficulty walking. They commonly experience a phenomenon called "freezing" in which they don't have the ability to initiate motion to produce functional movement. Given sufficient external stimuli the same patient will be able to overcome the problem and carry out productive movements. This can then lead to them walking forward. Standard visual cues may include lines of paint or tape on the ground, but these have limitations. We have created a walker which uses a laser to project a line onto the ground in front of the patient. The patient can then step over this line. As they move the walker forward, the same stimuli is presented automatically, enabling the patient to overcome the freezing and maintain walking. Our design is effective, safe, energy conserving, low cost and can enable the mobility of Parkinson's patients and prevent the disease from reaching its extreme stage.

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