Magnonics is a budding research field in nanomagnetism and nanoscience that addresses the use of spin waves (magnons) to transmit, store, and process information. The rapid advancements of this field during last one decade in terms of upsurge in research papers, review articles, citations, proposals of devices as well as introduction of new sub-topics prompted us to present the first Roadmap on Magnonics. This a collection of 22 sections written by leading experts in this field who review and discuss the current status besides presenting their vision of future perspectives. Today, the principal challenges in applied magnonics are the excitation of sub-100 nm wavelength magnons, their manipulation on the nanoscale and the creation of sub-micrometre devices using low-Gilbert damping magnetic materials and its interconnections to standard electronics. To this end, magnonics offers lower energy consumption, easier integrability and compatibility with CMOS structure, reprogrammability, shorter wavelength, smaller device features, anisotropic properties, negative group velocity, non-reciprocity and efficient tunability by various external stimuli to name a few. Hence, despite being a young research field, magnonics has come a long way since its early inception. This Roadmap asserts a milestone for future emerging research directions in magnonics, and hopefully, it will inspire a series of exciting new articles on the same topic in the coming years.
Acquired or inherent drug resistance is the major problem in achieving successful cancer treatment. However, the mechanism(s) of pleiotropic drug resistance remains obscure. We have identified and characterized a cellular metabolic strategy that differentiates drug-resistant cells from drug-sensitive cells. This strategy may serve to protect drug-resistant cells from damage caused by chemotherapeutic agents and radiation. We show that drug-resistant cells have low mitochondrial membrane potential, use nonglucose carbon sources (fatty acids) for mitochondrial oxygen consumption when glucose becomes limited, and are protected from exogenous stress such as radiation. In addition, drug-resistant cells express high levels of mitochondrial uncoupling protein 2 (UCP2). The discovery of this metabolic strategy potentially facilitates the design of novel therapeutic approaches to drug resistance.
We discuss some of the fundamental propenies unique to " i c multilayers. Complex spin configurations are examined for many different systems and are shown to arise i " a simple comptition between exchange and Zeeman energies. The spin configurations found in multilayer systems determine macroscopic properlies such as the static susceptibility and magnetization, and can lead lo anomalous 8eId and temperature behaviour. We also discuss the dynamic behaviour of magnetic multilayers. Emphasis is placed on spin waves in magnetic multilayers with canted spin configurations and the softening of modes at magnetic phase transitions. Funhermore we show that spin wave excitations provide a powerful method for studying exchange interactions and spin configdons. Finally, the phenomenon of giant magnetoresistance in magnetic multilayers, where the resistivity of the metallic structure 011 be changed by over 60% at mom temperature, is discussed. Simple theoreiicd approaches are used lo understand and predict the propertfes of the multilayer systems and comparisons between Wry and experiment are stressed.
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