The objective of the present study is to develop gastro retentive drug delivery system of Zanamivir .Floating tablets of Zanamivir were developed with a gas generating agent NaHCO3 and in combination of different hydrophobic and hydrophilic polymers like xanthan gum, guar gum, HPMC and methyl cellulose .In the present work attempts have been made to prepare six formulations of Zanamivir in different ratios of drug and polymer to get a desired release profile by direct compression method .All the prepared tablets were evaluated in terms of pre compression and post compression parameters. FTIR studies revealed the absence of drug polymer interactions .Among all the formulations F5 Showed 97.4% of in vitro drug release for 10 hours and hence formulation F5 is selected as an optimized formulation. The optimized formulation F5 was found to follow Higuchi release kinetics and zero order. Further formulation F5 was subjected to accelerated stability studies for 3 months. It showed that the optimized formulation was intact without any interactions. Finally the optimized formulation F5 complying with all properties of floating tablets was found to be satisfactory Keywords: Zanamivir, floating tablet, natural gums, sodium bicarbonate, gastro retentive drug delivery systems

Tuberculosis (TB) is a communicable systemic infectious disease with high morbidity and mortality associated with it. Resistance to medications used to treat tuberculosis has been on the rise in recent years. (multidrug-resistant tuberculosis)  (MDR-TB)  is a significant challenge to (TB) control around the world. An observational research was conducted in a tertiary care teaching hospital to determine the interim pharmacological and microbial results of Rifampicin resistance TB patients. Data from Santhiram Medical College and General Hospital, Nandyal, Kurnool Dist. Andhra Pradesh were obtained from Aug 2020 to Feb 2021, after receiving ethical approval from the Institutional Ethics Committee. The effects of the regimen are determined in terms of cure, finished treatment, treatment failure, number of patients moved to MDR-TB, number of patients who died in long-term MDR-TB regimen patients. Microsoft Excel 2007 was used to analyse the data. There were 82 male and 23 female out of 105 patients included in the study. Of these 75 patients were from rural areas and 40 from urban areas Using the Chi-square test and X2=12.1026, p=0.0005, which was important, the correlation between geographical spread and treatment result was determined. Out of 115 patients, 99 (86.09 percent) were cured of their disease, 06 (5.22 percent) died, 10 (8.69 percent) developed MDR-TB, and 2 (1.74 percent) were deemed medication errors. Males between the ages of 51 and 70 are more vulnerable to TB than females, according to our results. Compared to females of the same age, male patients over 40 years of age are more vulnerable to MDRTB. this was not part of the research objectives, emphasis should not be placed on this as either conclusion or recommendation.

Background: The management of type II diabetes mellitus is a complex, which requires continuous medical care by the health care professionals and good self-care efforts by patients. Pharmacist interventions programs delivered by the pharmacists are known to help the patients with diabetes benefited in achieving treatment goals, improving outcomes. Objectives: To study the impact of pharmacist interventions on therapeutic outcomes, determined by hemoglobin A1c (HbA 1c) and secondarily on blood glucose levels, blood pressure, medication adherence, self-care activities and health related quality of life. Materials and Methods: A Prospective randomized controlled study is conducted with 150 type II diabetic patients. Of those, 75 patients were in intervention group received the pharmacist interventions over a period of 4 months and 75 patients were in control group, whereas control group do not receive interventions. The primary outcome measure was change in HbA 1c and secondary outcomes were changes in fasting blood glucose, blood pressure, medication adherence, self-care activities and health related quality of life. Results: A population of 150 patients completed the study. The intervention patients exhibited a significant reduction in HbA 1c values than the control group, the intervention group showed a greater reduction in the fasting blood glucose and blood pressure levels between baseline and end of the 4 months than the control group. Improvements were observed in Quality of life, self-reported medication adherence, self-care activities in the intervention group. Conclusion: A pharmacist interventions program resulted in better glycemic control, quality of life, medication adherence and self-care of type II diabetic patients over a 4-month period.

Cardiovascular diseases and Cerebro-vascular diseases account for majority of the burden of NCDs. Stroke is one the major component of these, posing public health challenges. 1 in 6 people suffer with stroke in their life time. The impact of stroke can be short or long term, depending on which part of the brain is affected and how quick it is treated. This hospital based case                       study was undertaken with aim to study the prescribing pattern and the functional outcomes in cerebral stroke. Study was carried out in the Santhiram Medical hospital, Nandyal, Andhra Pradesh, India. Methodology: Patients visiting the neurology clinic were asked to answer the questionnaire covering functional outcomes by using functional assesment scales to determine the clinical status of the patient; Most of the patient’s data were collected from case sheets. A total of 150 patients were included in the observational study. Data from case sheets were analysed to assess the prescribing pattern and the questionnaires like mRS, SSQOLS, MMSE scales were used to interview the stroke patients to assess the functional outcomes. Results: Our study presents that there is a minimal Modified Rankin Scale (MRS) score progress in patients. MRS, SSQOL, MMSE scales, which showed improvement in the quality of life and cognition in stroke patients after treatment. Conclusion: In conclusion, that significant functional gains in rehabilitation process of                         stroke can be attained by combination therapy, lifestyle changes, and better management of risk factors said to possess the major effect on recovery of stroke with improved quality of life and symptoms.

Coronary artery disease otherwise named as Coronary heart disease. Coronary Artery Disease means narrowing of the coronary arteries. This narrowing causes reduction of blood flow to the heart muscle by buildup of plaque in the arteries of heart. A common symptom of Coronary artery disease is chest pain or chest discomfort which can travel to the shoulder, arm, back, neck or jaws. Other symptoms may include Shortness of breath, palpitations and even fatigue. Majorly antiplatelets are given in the treatment of CAD and followed by angioplasty for the clearing of plaques in the coronary artery. Collected a sample size of 200 patients, among them 126 are males and 74 are females. Patient with age group of 51-60 are more prone to CAD in both males and females. Chest pain is majorly seen in males compared to females. Chest pain, Sweating and shortness of breath is seen in both males and females and the number of male patients are more when compared to females. Patients with only shortness of breath are less when compared to other chief complaints. Social history includes Smokers are 26 (47.2%), alcoholic are 48 (57.14%).. Among all these patients the length of hospital stay of patients treated with combination of aspirin and clopidogrel is less when compared with ticagrelor, aspirin, clopidogrel.Based on the follow up observations we may consider that combination of antiplatelet therapy is effective in CAD patients undergone with percutaneous transluminal coronary angioplasty.