Objective: To determine the prevalence of hypothyroidism in a rural population of Nandyal.Methods: A prospective study was conducted in Santhiram medical college and general hospital, Nandyal from July 2017 to December 2017, to study the prevalence of hypothyroidism among the population. Results: In this study, 1000 patients were evaluated for the thyroid functioning, among them n=104(10.4%) showing positive results in hypothyroidism. The positive 104 patients showed that n=63 (60.57%) of the population are in the age limit of 21-40. Out of the same population are n=11 (10.6%) are male and female are n=93 (89.43%). In age group distribution more prevalence was observed in 21-30 y of age group n=36 (34.61%). In this study, sub-clinical hypothyroidism was prevalent in females n=80 (76.92%) than males n=10 (9.61%).Conclusion: Our study demonstrates that hypothyroidism was higher in a female with age group as 21-40 y and there is a significant prevalence of hypothyroidism in the study population.

Present study is aimed at the development of oro-dispersible tablets of clonazepam using natural superdisintegrants. Mucilage of Hibiscus rosa sinensis leaf and seeds of Ocimum basilicum were extracted, evaluated for the organoleptic, physicochemical parameters. The dried mucilage was used as superdisintegrant for the preparation of orodispersible tablets by direct compression method. The blends were evaluated for the pre-compression parameters and all the formulations were found to possess good flow properties. Tablets were compressed by direct compression technique, evaluated for weight variation, hardness, thickness, friability, water absorption, disintegration time, dispersion time, drug content and dissolution studies. The drug release profiles of the two superdisintegrants were compared. The optimized formula F10 was subjected to wet granulation using PVP in IPA as the dry binder. The tablets containing 5%w/w dried mucilage of Ocimum basilicum as superdisintegrant prepared by direct compression technique was found to be the best which disintegrated in 22 sec. with 99.8%drug release. The tablets were found to be stable during the accelerated stability studies conducted for three months at 40±2 0 C/75±5% RH.

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Background: The management of type II diabetes mellitus is a complex, which requires continuous medical care by the health care professionals and good self-care efforts by patients. Pharmacist interventions programs delivered by the pharmacists are known to help the patients with diabetes benefited in achieving treatment goals, improving outcomes. Objectives: To study the impact of pharmacist interventions on therapeutic outcomes, determined by hemoglobin A1c (HbA 1c) and secondarily on blood glucose levels, blood pressure, medication adherence, self-care activities and health related quality of life. Materials and Methods: A Prospective randomized controlled study is conducted with 150 type II diabetic patients. Of those, 75 patients were in intervention group received the pharmacist interventions over a period of 4 months and 75 patients were in control group, whereas control group do not receive interventions. The primary outcome measure was change in HbA 1c and secondary outcomes were changes in fasting blood glucose, blood pressure, medication adherence, self-care activities and health related quality of life. Results: A population of 150 patients completed the study. The intervention patients exhibited a significant reduction in HbA 1c values than the control group, the intervention group showed a greater reduction in the fasting blood glucose and blood pressure levels between baseline and end of the 4 months than the control group. Improvements were observed in Quality of life, self-reported medication adherence, self-care activities in the intervention group. Conclusion: A pharmacist interventions program resulted in better glycemic control, quality of life, medication adherence and self-care of type II diabetic patients over a 4-month period.