The present investigation is aimed to prepare the sustained release beads of carbamazepine using different proportions of talc and sodium alginate for sustained delivery of carbamazepine. The proposed beads were formulated using the inotropic gellan method. The drug to talc to polymer ratio in optimized batch S 2 was kept at 1 : 0.5 : 0.3. The obtained beads were characterized for its particle size distribution, percent drug content, mean diameter and crushing strength, thermal analysis (DSC), crystallinity (PXRD), surface morphology (SEM), and in vitro drug release. The prepared beads were found to be optimal in terms of particle size and entrapment efficacy. There were no compatibility issues and the crystallinity of drug was found to be reduced in prepared microspheres, which were confirmed by DSC and PXRD studies. The time to release 70% of drug from all batches of beads were in the range of 0.5-3.0 h, which could be used to prevent the formation of carbamazepine dehydrate form (CBD) having one third solubility of carbamazepine and high extent of drug release. The drug was sustained for optimized batch S 2 was 5 hour. Further investigations are required to reduce the amount of polymer in microspheres that can provide maximum drug loading and acceptable dosage form.

Numerous natural polymers either alone or in combination with other polymers were found effective in controlling the drug release. In this study the attempts were made to combine chitosan (degree of deacetylation 84.14 %) and as hydroxylpropyl methylcellulose (HPMC K 15M) to retard the release of aceclofenac in tablet formulation. The tablets were prepared by wet granulation and evaluated for pre and post- compression parameters. All the pre-compression parameters were found within the limit.  Hardness and friability values were found in the range of 4.30-4.89 kg/cm2 and 0.1-0.6% respectively. These results proved the good mechanical strength of the formulations.  The drug content was found in the range of 97.56 – 99.10 %.  Weight variation was found within the official limit. The percent drug release and swelling index was found to be dependent on the concentration of polymer. With increasing the concentration of both the polymers the swelling index was increased and drug release decrease. Highest concentration of both the polymers was found to retard the drug release up to 8 h.  The effect of Chitosan and HPMC on drug release was evaluated by design expert software to achieve the optimized formulation. The response of the drug release after 4h was considered to check the drug release. It was found that the enhanced concentration of both the polymers had negative effective on the drug release. The formulation containing highest concentration of the chitosan and HPMC was found be fit in the limits of optimized formulations. The optimized formulation was found to be stable at accelerated stability storage conditions.