No abstract

The hydantoin derivatives may cause various types of drug reaction, the best known being the hyperplasia and hypertrophy of the gums, which is seen more commonly in children than in adults. A lupus erythematosus-like syndrome can occur during hydantoin therapy and in some reports the incidence of positive L.E. cells has been shown to be relatively high. Other complications which have been recorded with the hydantoin derivatives are megaloblastic anaemia, aplastic anaemia, leucopenia, agranulocytosis, thrombocytopenia, methemoglobinaemia, gastrointestinal symptoms and cerebellar dysfunction with vertigo, ataxia, dysarthria and nystagmus ( M e y l e r 1965), The dermatological side effects which have been described include generalised morbilliform and scarlatiniform rashes, lupus erythematoses-like eruptions, erythrodermia, erythema multiforme ( Stevens-Johnson's syndrome), toxic epidermal necrolysis (LyeI1) , hyperpigmentation of the chloasma type

SRD441 ointment did not demonstrate efficacy in the treatment of atopic dermatitis raising questions on the effectiveness of MMPs as a target for the treatment of atopic dermatitis. NCT00882245.

Two occlusive dressings--one zinc oxide medicated (Mezinc) and one hydrocolloid (Duoderm)--were compared in a prospective, randomized trial over a period of 8 weeks to determine their healing ability and effect on pain for venous and arterial leg ulcers. All patients were patch-tested before the study and colophony allergy was an exclusion criterion. Of the 43 outpatients included, 31 completed the trial and 6 patients randomized to each treatment group were withdrawn. The initial ulcer areas decreased after 8 weeks of treatment with Mezinc by 64% and by 48% after treatment with Duoderm. Ulcer pain was relieved in 50% of the patients--with a similar analgesic effect for the two dressings. Mezinc treatment was discontinued in 2 cases due to sensitization to colophony (one ingredient of Mezinc) which indicated a risk of contact allergy to colophony due to Mezinc treatment. 1103 consecutive eczema patients were patch-tested on the back with Mezinc and colophony 20% in petrolatum simultaneously. It was found that 42 (4%) of the patients showed allergic skin reactions to colophony and 19 (2%) to Mezinc. Both dressings were well tolerated by leg ulcer patients and there appeared to be no major differences in the efficacy of the two occlusive dressings.