CF101 was well tolerated and demonstrated clear evidence of efficacy in patients with moderate to severe plaque psoriasis.

Obesity and poor glycemic control in patients with DM2 affect key immunological components of IgE-mediated allergic inflammation and possibly alter the immune response to allergens and antigens.

Adult acne (AA) is defined as acne that develops (late-onset acne) or continues (persistent acne) after 25 years of age. 1 Epidemiological data demonstrate that AA can affects approximately 30-50% of the adults. 2 In women, the disease incidence is increasing, and for this, it is also named adult female acne (AFA). 3 The clinical features of AFA are quite specific: inflammatory acne lesions in the lower facial region or macro comedones (microcysts) spread over the face. 4 In fact, AFA commonly affects the lower third of the face and the jawline and its incidence is increasing. AFA seems to be particularly frequent among adult female smokers, even if there is not concordance

BackgroundMastocytosis is a rare disorder with diverse clinical manifestations. In cutaneous mastocytosis the mast cell infiltration is limited to the skin, but is often associated with systemic symptoms due to the release of mast cell mediators.Case ReportWe report a 6-month-old male infant who had skin lesions of various morphologies (macules, papules, plaques, and nodules) and sizes, persistent blistering and frequent flushing episodes for half a year. Vital signs and physical examinations were unremarkable. No abnormalities in the laboratory tests were found except for a serum tryptase level (STL) of 11.8 ng/ml. The histological and immunohistochemical examinations confirmed the diagnosis of cutaneous mastocytosis. The patient was first treated with methylprednisolone, oral levocetirizine, and topical fusidic acid/betamethasone cream. Subsequently the treatment was tapered and stopped within 9 weeks. The child’s symptoms improved and were successfully controlled with intermittent courses of ketotifen and topical hydrocortisone over 3 years.ConclusionChildhood cutaneous mastocytosis usually has a favorable prognosis, but in some cases the disease can progress with skin manifestations necessitating a more active systemic and topical treatment.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-015-0073-6) contains supplementary material, which is available to authorized users.

SRD441 ointment did not demonstrate efficacy in the treatment of atopic dermatitis raising questions on the effectiveness of MMPs as a target for the treatment of atopic dermatitis. NCT00882245.