Postpericardiotomy syndrome (PPS) is a frequent complication after cardiac surgery. In a recent study, elevated anticardiolipin antibody (ACLA) titres were observed in patients with PPS. The value of anti-heart muscle antibodies (AHA) for the diagnosis of PPS remains controversial. Therefore, a prospective double-blind study was performed to test the sensitivity and specificity of ACLA and AHA for the diagnosis of PPS. ACLA titres (ELISA) and AHA, elevated by immunofluorescence, the clinical course and routine laboratory parameters were assessed in 57 patients before and after elective cardiac surgery. ACLA increased and AHA first appeared after surgery in patients both with and without PPS. The sensitivities of a > or = 1.5-fold increase in IgM-ACLA titres, of a > or = 2-fold increase in IgG-ACLA titres and of the occurrence of AHA > or = 2+ for the diagnosis of PPS were 60%, 20% and 20%. The respective specificities were 43%, 79% and 85%. Thus, after cardiac surgery, increased ACLA titres and the occurrence of AHA, as assessed by immunofluorescence, may only contribute to the diagnosis of PPS to a limited extent.

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Schlüsselwörter: Blutdruck (Hypotension), computergesteuerte Infusion, Vasodilatatoren, Nitroprussid Eine computergesteuerte Infusionstherapie mit kurzwirkenden Vasodilatatoren zur raschen und zuverlässigen Senkung eines gesteigerten Blutdruckes wird vorgestellt. Die automatische Steuerung erreicht gegenüber der herkömmlichen Applikationsart eine höhere Stabilität der Blutdruckeinstellung und bedeutet eine Arbeitsentlastung für das Personal. A Computer controlled infusion of short-acting vasodilating drugs for rapid and reliable reduction of increased blood-pressure is described in the following article. In comparison with conventional management the automatic device achieves greater stability of blood-pressure regulation and saves work for the staff.Schlüsselwörter: Microcomputer, Spritzenpumpe, Sicherheitsüberwachung Es wird gezeigt, daß mit der Anwendung der Microcomputertechnologie in Infusionsapparaten ein nicht nach bisherigen Verfahren prüfbares Bauelement übernommen wird, das völlig neuartige Sicherheitsprobleme aufwirft. Am Beispiel einer Spritzenpumpe wird eine Sicherheitsstruktur mit einem Microcomputer erläutert, die diese Sicherheitsproblematik umgeht, und die die komplexen Eigenschaften des Microcomputers in wirtschaftlicher und technischer Sicht überzeugend nutzt.Key-words: Microcomputer, injection pump, safety monitoring It is shown that the employment of microcomputer technology in infusion equipment is associated with completely novel problems of safety, since this new component does not lend itself to the usual forms of testing used with conventional components. Using an injection pump äs an example, it is shown how the safety problems associated with a microcomputer can be dealt with, and how the complex properties of the microcomputer can be convincingly utüized both economically and technically.Brought to you by | University of Alberta Library Authenticated Download Date | 6/28/15 8:37 PM

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