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The depressing effect of dietary cadmium on blood hemoglobin has been demonstrated in several species (1-3). A mutual antagonism ,between ,Cd and Zn has been established (3-7) and a partial amelioration of cadmium toxicity in the chick was noted with Cu fed in conjunction with 100 ppm of Zn (1). With Zn at 25 ppm, both Fe and Cu supplements were shown to ameliorate Cd toxicity.Cadmium decreases longevity in male mice and possesses innate toxicity (8). These toxic properties of Cd make it desirable to elucidate the factors which will minimize the adverse effects on animals of environmental Cd contamination. The present experiments were undertaken to test the interactions between dietary Cd, Fe, and Zn in the growing rat with respect to effect on body weight gain, blood hemoglobin concentration and tissue levels of trace elements.To test these interactions, weanling rats were fed diets identical in all respects, within each experiment, except for the level of Cd, Fe, and Zn. These trace elements were added

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