An improved method for the synthesis of some new dihydropyrimidines from aromatic aldehydes, 1,3‐dicarbonyl compounds, and thiourea with significant enhancement in reaction rates, short reaction time (4–6 h), good to excellent yields (70–93%), and ambient temperature using molecular iodine as catalyst is described. The biological evaluation revealed that the newly synthesized compounds 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j and 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j exhibited good antimicrobial activity and moderate antimycobacterial activity against Mycobacterium tuberculosis H37RV.

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in Wiley Online Library (wileyonlinelibrary.com).Heterosubstituted chalcones and oxopyrimidines were synthesized by the reaction of 2-(4-Chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 1 and different aryl acetophenone in the presence of catalytic amount of 40% alkali to give (2E)-3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-1-arylprop-2-en-1-ones 2a-l. Compounds 2a-l on reaction with urea in the presence of basic catalyst such as KOH to give 6-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-4-aryl pyrimidin-2(1H)-ones 3a-l. Their IR, 1 H-NMR, MASS spectral data, and elemental analysis were in accord with assigned structure. All the newly synthesized compounds were screened for their antimicrobial activity.

The highest activity against B.