The main goal of glaucoma treatment is to preserve visual functions and quality of life of patients. In recent years, in connection with the development of vitreoretinal surgery, a number of complications has appeared, one of which is ophthalmic hypertension and progressive glaucomatous damage to the optic disc. An analysis was made of the surgical treatment of 12 patients (12 eyes) with secondary glaucoma after vitreoretinal surgery with the removal of SO 1300 according to gonioscopy-assisted transluminal trabeculotomy (GATT) technique in order to evaluate efficacy and safety. Key words: glaucoma; secondary glaucoma; gonioscopy-assisted trabeculotomy; minimally invasive glaucoma surgery; surgical treatment of glaucoma; silicone oil.

The study included 59 eyes after vitrectomy with silicone oil and gas tamponade. The 1st group (31 eyes) consisted of cases with silicone oil 1300 cSt tamponade, the 2nd group (28 eyes) – cases with C2F6 gas tamponade. Perpose. To compare changes in morphological parameters of ganglion cells and the morphological structure of the retina after vitrectomy with gas and silicone oil tamponade due to rhegmatogenous retinal detachment. Results. BCVA in the 1st group was reduced compared to the 2nd group, amounting to 0.4 [0.2; 0.5] in the 1st group and 0.5 [0.3; 0.6] (U = 242.500, p = 0.044) in the 2nd group. In the 1st group ERM occurred 4.1 times more often than in the 2nd group (χ² = 4.391, df = 1, p = 0.036). Macular edema in the outer nuclear layer was detected only in the 1st group in 16 % of cases (χ² = 4.766, df = 1, p = 0.029). Macular edema in the inner nuclear layer in the 1st group was 5.7 times more common than in 2nd group, amounting to 22.6 % and 4 %, respectively (χ² = 4.325, df = 1, p = 0.029). Ellipsoid zone defect was detected in 22.6 % of cases in the 1st group and in 32 % of cases in the 2nd group (χ² = 0.835, df = 1, p = 0.361). The focal loss volume of retinal ganglion cells in the 1st group was 8.5 times higher than in the 2nd group (U = 158.500, p = 0.009) A statistically significant difference was obtained for the Intra Eye GCC parameter, amounting to -5.0 [-8.25; 1.0]* in the 1st group and 0.0 [-3.0; 6.0] in the 2nd (U = 146.500, p = 0.004). Conclusion. According to visometry in the postoperative period for rhegmatogenous retinal detachment using silicone oi tamponade with a duration of 80.0 [59.0; 120.0] associated with a lower functional result compare to gas tamponade, accompanied by a more frequent formation of ERM, cystoid macular edema and an increase in focal loss volume of ganglion cell complex compared to gas tamponade.

Purpose. To compare the morphological and functional outcome after vitrectomy with gas and silicone oil tamponade due to rhegmatogenous retinal detachment. Material and methods. The study included 59 eyes after vitrectomy with silicone oil and gas tamponade. The 1st group (31 eyes) consisted of cases with silicone oil 1300 cSt tamponade, the 2nd group (28 eyes) – cases with C2F6 gas tamponade. Results. According to OCT data, in patients of the 1st group an epiretinal membrane occurs 4.1 times more often than in patients of the 2nd group (χ²= 4.391, df= 1,p= 0.036), cystic edema of the outer nuclear layer and the layer of Henle fibers was detected only in the 1st group in 16 % of cases (χ²= 4.766, df= 1, p = 0.029), pseudocysts and cysts of INL predominated in the 1st group (χ²= 4.325, df= 1, p=0.029). Fundus microperimetry revealed a lower value of retinal sensitivity in the group with silicone oil tamponade. In zone I it was 20 [13.0; 22.0] and 21 [20; 23] for the 1st and 2nd groups respectively (U = 183.500, p = 0.025). In zone II, a decrease was found in the upper temporal 21 [15.2; 24.5] and 23.5 [21.5; 24] (U = 176.000, p = 0.018), upper nasal 20 [16; 22.5] and 23.5 [ 20.5; 24.5] (U = 138.000, p = 0.002) and lower nasal sector 22.0 [19.0; 23.0] and 23.0 [20.5; 24] (U = 189.000, p = 0.034) for the 1st and 2nd groups respectively. In zone III, the decrease is demonstrated in the upper temporal and upper nasal quadrants, amounting to 23 [20.5; 24] and 24 [23; 25.5] (U =184.5, p =0.027); 22 [16.75; 23] and 23.5 [22.5; 25] (U =184.5, p =0.004) for the 1st and 2nd groups respectively. In zone IV, changes were detected in the nasal sectors, amounting to 21.5 [17.5; 23] and 23.5 [22; 25] (U =137.500, p = 0.002) in the upper nasal sector, 21.5 [19; 23,0] and 23 [21.5; 24.0] (U = 183.000, p = 0.025) in the lower nasal sector for the 1st and 2nd groups, respectively. Conclusion. The use of silicone oil tamponade is associated with lower retinal sensitivity compared to gas tamponade. Keywords: rhegmatogenous retinal detachment, microperimetry, silicone oil endotamponade.

Aim. To evaluate the morphological and functional parameters of the retina after subretinal administration of recombinant prourokinase followed by endovitreal tamponade with an air-gas mixture without vitrectomy in comparison with antivasoproliferative therapy in patients with subfoveal hemorrhages. Methods. Patients of the first group at the 1st stage underwent two-port 27 G surgery with controlled subretinal injection of recombinant prourokinase solution (500 IU) through a 38 G cannula with tamponade of 1/5 of the vitreous cavity volume with air-gas mixture. At stage 2, therapy with antivasoproliferative drugs was prescribed according to the treat and extend regimen. Patients in the control group received antivasoproliferative therapy as the main treatment. Results. In group 1, there was a trend towards an increase in best corrected visual acuity (BCVA) throughout the entire observation period: on the 14th day after the 1st stage of treatment it was 0.18±0.05 (p < 0.05 compared to before treatment), after 3 loading injections 0.3±0.1, while there was an increase in photosensitivity values up to 4.7±2.2 dB (p < 0.05 in comparison with the values before treatment) and up to 12.6±4.6 dB (p < 0.05 in comparison with the indicators before treatment, the indicators of the 2nd group, respectively). An inverse correlation of functional parameters was noted against the background of depression of the central retinal thickness up to 222.0±60.7 µm and the height of the neovascular membrane up to 72.0±23.0 at the end of observation. Conclusion. Use of subretinal administration of recombinant prourokinase followed by endovitreal tamponade with an air-gas mixture without vitrectomy demonstrates an increase in BCVA with a decrease in the area of absolute scotoma with an increase in the overall photosensitivity of the macular zone against the background of improved anatomical parameters. Timely appointment of antivasoproliferative therapy in the postoperative period ensures preservation of morphofunctional results achieved after surgery. Key words: submacular hemorrhage; tissue plasminogen activator; pneumodislocation; age-related macular degeneration.