This study was designed to evaluate the efficiency of Endolift®, a novel minimally invasive outpatient laser procedure, for the nonsurgical treatment of eyelid ptosis. Thirty patients aged 30 to 55, 15 women and 15 men, were enrolled on this study. All patients had skin ptosis of the upper eyelids and the eyebrow area and dropping of the lateral part of the eyebrow. Patients have undergone a single treatment under micro drops of local anaesthesia. Treatment was performed using the Endolift® procedure, consisting of the device Eufoton® LASEmaR® 1500. This device uses a 1470 nm wavelength laser lead by micro-optical fibres of different calibres directly inside the skin. Twenty-four reported optimal results, 4 very good and 2 moderate. The first results were visible after 5 to 14 days and improved over time, and the average downtime was between 2 and 3 days due to the swelling. No other side effects were observed. These data confirm that Endolift® is a safe and effective procedure for the nonsurgical treatment of eyelid ptosis representing a real alternative to surgery.