Lyell’s syndrome commonly known as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is a type of severe allergic reactions affecting the skin and mucous membranes. If surface area of the body (BSA) involvement is less than 10% which is called as SJS and TEN is defined as epidermal detachment >30% of the total body surface area while both SJS and TEN can have involvement of mucosa. BSA with 10–30%, there is overlapping of SJS and TEN. We report a rare, life-threatening case of Lyell’s syndrome who presented lesions involving 30% of BSA after the oral intake of phenytoin and she was successfully treated with high-dose steroids and supportive care.

A 54-year-old, right-handed male presented with acute-onset severe headache, vertigo, and vomiting. Initial neurologic examination illustrated dysarthria (lingual), nystagmus (horizontal), left dysmetria on finger-to-nose testing, and weakness of the left upper and lower limb. Magnetic resonance imaging showed left lateral medullary infarction (Wallenberg syndrome). The patient was discharged 3 weeks later to an inpatient treatment with neurorehabilitation facility with gradual improvement of his symptoms.

Limb girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy are caused by similar mutations in the dysferlin gene. The phenotype of these allelic disease variants can vary considerably. We report a young male with severe and rapidly progressing muscle disorder with increased creatine phosphokinase (CPK) and confirmatory muscle biopsy findings. Genetic testing was done. A homozygous nonsense variation in exon 23 of the DYSF gene, which was consistent with the patient’s clinical reports of dysferlinopathy. Clinical phenomenology and preferential muscle involvement lead one to the gold standard genetic testing in heritable myopathies, which was well established in this report.

Melioidosis is caused by Burkholderia pseudomallei which is a soil-dwelling aerobic bacterium reported mostly in tropical and subtropical areas, especially in Asia (Southeast) and Australia (Northern part). Melioidosis is a severe infection that can manifest as chronic debilitating pneumonia mimics pulmonary tuberculosis. Here, we reported a case of melioidosis, in 51-year-old men with poorly controlled type 2 diabetes mellitus. The patient recovered with appropriate intravenous antibiotics and supportive medications.