Lyell’s syndrome commonly known as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is a type of severe allergic reactions affecting the skin and mucous membranes. If surface area of the body (BSA) involvement is less than 10% which is called as SJS and TEN is defined as epidermal detachment >30% of the total body surface area while both SJS and TEN can have involvement of mucosa. BSA with 10–30%, there is overlapping of SJS and TEN. We report a rare, life-threatening case of Lyell’s syndrome who presented lesions involving 30% of BSA after the oral intake of phenytoin and she was successfully treated with high-dose steroids and supportive care.

A 54-year-old, right-handed male presented with acute-onset severe headache, vertigo, and vomiting. Initial neurologic examination illustrated dysarthria (lingual), nystagmus (horizontal), left dysmetria on finger-to-nose testing, and weakness of the left upper and lower limb. Magnetic resonance imaging showed left lateral medullary infarction (Wallenberg syndrome). The patient was discharged 3 weeks later to an inpatient treatment with neurorehabilitation facility with gradual improvement of his symptoms.

Thrombosis of the venous system in the brain is a cause of cerebral infarction, second only to arterial disease, but is associated with high levels of morbidity and mortality. The clinical picture of cerebral venous thrombosis is highly variable and often presents a source of confusion to physicians. This study aimed to establish the clinical picture of cerebral venous thrombosis in patients in a tertiary healthcare center. We collected and analysed the case records of 23 patients with CVT. The most predominant presenting complaint was headache (47.8%) followed by vomiting (26%). The most common site of involvement was found to be the superior sagittal sinus (34.8%). Multiple sites of involvement were more common than a single site.

The thalamus is a walnut-sized structure that is located in the brain which receives rich blood supply from posterior cerebral artery and its communicating branches. One of the unusual presentations is the infarction of artery of percheron. Hereby reporting a case of 68-year-old female with no known co-morbidities who presented to the emergency department with complaints of sudden onset loss of consciousness in the morning. On further investigation, was found to have infarction of one of the variants of thalamic perforating arteries.

Limb girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy are caused by similar mutations in the dysferlin gene. The phenotype of these allelic disease variants can vary considerably. We report a young male with severe and rapidly progressing muscle disorder with increased creatine phosphokinase (CPK) and confirmatory muscle biopsy findings. Genetic testing was done. A homozygous nonsense variation in exon 23 of the DYSF gene, which was consistent with the patient’s clinical reports of dysferlinopathy. Clinical phenomenology and preferential muscle involvement lead one to the gold standard genetic testing in heritable myopathies, which was well established in this report.