The spread of dermatophytosis among animals and humans in the localities of Ukraine in particular in the city of Kharkiv is due to the presence of range of the most susceptible animals. This information mainly concerns dogs and cats that can be affected by dermatophytosis and may be a reservoir of dermatophyte fungus. Particularly important is that domestic dogs and cats represent a significant epidemiological threat to the population. The purpose of the research was to monitor the morbidity of dermatophytosis in domestic dogs and cats in Kharkiv. Diagnostic studies of dermatophytosis morbidity level determination in domestic dogs and cats were performed complexly including the clinical and epizootic data, microscopic and mycological laboratory tests conducted according to generally accepted methods (Kovalenko et al., 2017; Sutton, Fothergill and Rinaldi, 2001). Dermatophytosis was diagnosed among 231 animals in the study of 1,277 domestic dogs kept by the inhabitants of the city of Kharkiv which was in 18.09% of samples. Dermatophytosis was also detected in 615 animals which constitutes 50.25% in the study of 1,124 cats. The cultures of dermatophytosis agent Microsporum canis were isolated from 126 dogs (18.98%) and 110 cats (40.74%). Trichophyton mentagrophytes cultures were isolated from 16 dogs (2.41%) and 16 cats (5.93%). The percentage of isolated cultures of mold and yeast-like fungi in the studies of sick dogs and cats were 38.55% and 22.25% respectively. Obtained results indicate quite high level of the dermatophytosis spreading among domestic dogs and cats in the city of Kharkiv.

Feline respiratory infectious diseases have spread to many countries around the world. The isolation of a specific pathogen and its identification are of great importance. It is also important for the use of specific agents for the treatment and prevention of these diseases.In 2019-2020 the studies at the private veterinary clinic «Aibolit» in Kharkiv were conducted in the conditions of private breeding cattery for cats in the city and using the equipment of the educational -scientific laboratory of molecular -genetic research methods at KHZVA.Materials for research were cats of different breeds and sex-age groups with clinical signs of respiratory diseases, as well as biomaterials from them (blood and nasal discharge), which were studied both by virological methods and PCR.The nosological profile of respiratory infectious diseases of cats in Kharkiv is formed by 3 nosological units. In 24% of cases, the clinical manifestations of rhinotracheitis in cats were caused by the association of two or three pathogens (calicivirus, herpesvirus and chlamydia). The herpes viruses accounted for 33.1% of the total samples of cats' biomaterials that were examined.From animals with infection using PCR herpes virus was isolated in 83.8% of cases. In 55 cases (42.6%) this virus was the only pathogen that was detected.The analysis of the disease of cats taking into account their age showed that rhinotracheitis was more often affected by young cats at the age of 1.5-3.5 months to 5.5 years and older. Cats that were kept individually and in groups were ill.Cats of certain breeds were sick. Cases of the disease were recorded more often in spring and autumn.The disease proceeded in respiratory, conjunctival and less often in genital forms.The main pathway to isolate the rhinotracheitis pathogen into the external environment was respiratory, with outflows from the nasal cavity of animals, where they were detected in an amount of 2.03 ± 0.12 lg TCD 50 / ml -2.05 ± 0.16 lg TCD 50 / ml. (by age group) even with latent infection. The pathogen was isolated in 38,4% of cats with clinical manifestations of the disease using PCR. In 23.8% of cases the herpes virus was isolated as the only pathogen.

Porcine enzootic pneumonia is a multifactorial disease, it leads to large and significant economic losses in pig farms and it remains a relevant veterinary problem. The involvement of new etiological agents in the association of pathogens and the constantly changing conditions on the farms lead to the fact that previously developed control schemes and methods of disease lost their effectiveness. Therefore, the identification of all the infectious agents that make up the association, as well as the concomitant factors that led to the occurrence of the disease in each case is the only correct way to control measures.When we studied the situation in pig farms in the south and in the central region of Ukraine, we found that mycoplasmas were the main etiological agent for Porcine enzootic pneumonia. We noted that mycoplasmosis as a monoinfection was recorded only in 9-12 % of cases. In most outbreaks Mycoplasmas were only members of associations along with Porcine reproductive and respiratory syndrome infection (6%), Type 2 Circovirus infection (6%), enterbacterias (19%) and pasterellas (59%).The course of the disease was also aggravated by the stress of early weaning of piglets and violations of the conditions of feeding and animal welfare.The most difficult enzootic pneumonia occurred in those farms where mycoplasmosis and pasteurellosis were exacerbated by the presence of pathogens of actinobacillus pleuropneumonia. In such farms the average daily weight gain decreased in piglets by a third and feed consumption increased to 28 %.Piglets on affected farms were ill with obvious respiratory clinical signs. And 82% of dead or killed piglets had signs of fibrinous pleuropneumonia or catarrhal pneumonia.In those farms where we recorded associated respiratory infections, we also found reproductive-neonatal infections of pigs.In such farms treatment and prophylactic measures using traditional antimicrobial special remedies and monovaccines, did not give the expected effect.We proposed the use of autovaccines for associated enzootic pneumonia.

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