Blattella germanica L. is a residential pest that can be a disease vector. One of the ways to control Blattella germanica is using toxic baiting. Fipronil and imidacloprid are chemicals used to kill cockroaches. The aim of this study is to compare the effectiveness of the active substances Fipronil and imidacloprid used to control the Blattella germanica. The methods of this study were test insects preparation, making toxic bait, toxic bait effectiveness test, mortality and data analysis calculation. The data were analyzed statistically using One Way ANOVA test and probit analysis. ANOVA test results obtained a significance value of 0.00 (P < 0.05), this indicated that there was a significant difference in the mortality percentage between the treatment groups. The highest deaths percentage occurred in the Blattella germanica group that was treated with a combination of bait and the active substance Fipronil. In addition, the lowest LT50 and LT90 occurred in the LT50 = 28.23 hours and LT90 = 72.10 hours. These results showed that the active substance Fipronil was more effective in controlling the Germany’s cockroach compared to imidacloprid.