The BFI is a valid and reliable instrument for the assessment of opioid-induced constipation in chronic pain patients. Psychometric analyses from clinical trials support the BFI's psychometric properties.

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linear regime by introduction of the large-signal capacitance, a parameter that is scarcely defined for NLTLs acting as frequency multipliers. The LSSP simulation does not require the introduction of C ls , and is able to provide the frequency response by taking the actual operating conditions (power level of feeding signals) and device nonlinearity into account. Because the filtering properties of NLTLs have a direct influence on circuit performance, the LSSP simulation approach is a powerful tool for the design of NLTL frequency multipliers. CONCLUSIONSIn this Letter, two important aspects of NLTL simulation have been considered: the degree of accuracy provided by the lumpedelement approach and the analysis of the transmission properties under large-signal conditions. It has been demonstrated that the lumped-element model can be used to study the linear and nonlinear behavior of the circuit, if the shunt capacitance dominates the per-section capacitance of the line. Large-signal S-parameter simulation has been demonstrated to be a powerful technique for the study of the filtering properties of NLTLs under nonlinear operating conditions. REFERENCES 1. R. Hirota and K. Suzuki, Theoretical and experimental studies of lattice solitons in nonlinear lumped networks, Proc IEEE 61 (1973)