With the vision to transform the current wireless network into a cyber-physical intelligent platform capable of supporting bandwidth-hungry and latency-constrained applications, both academia and industry turned their attention to the development of artificial intelligence (AI) enabled terahertz (THz) wireless networks. In this article, we list the applications of THz wireless systems in the beyond fifth generation era and discuss their enabling technologies and fundamental challenges that can be formulated as AI problems. These problems are related to physical, medium/multiple access control, radio resource management, network and transport layer. For each of them, we report the AI approaches, which have been recognized as possible solutions in the technical literature, emphasizing their principles and limitations. Finally, we provide an insightful discussion concerning research gaps and possible future directions.

Abstract:The results of directly comparing the prediction accuracy of optimized 3D Quantitative Structure-Activity Relationship (3D-QSAR) models and linear Support Vector Machine (SVM) classifiers to identify small molecule inhibitors of the BRAF-V600E and HIV Integrase targets are reported. Performance comparisons were carried out using 303 compounds (68 active) against BRAF-V600E and 204 compounds (159 active) against HIV Integrase. A SVM prediction accuracy of 95% (BRAF-V600E) and 100% (HIV Integrase) and 3D-QSAR prediction accuracy of 76% (BRAFV600E) and 82% (HIV Integrase) was observed. To help explain the better performance of SVM in the comparison reported here and to help assess the degree to which a SVM or 3D-QSAR model is likely to perform best for other targetligands of interest a new EPP (Expected Predictive Performance) metric is introduced. How EPP can be used to help predict future performance of SVM and 3D-QSAR models by quantifying the degree of similarity between candidate compounds and training data is also demonstrated. Results show that the EPP metric is capable of predicting future prediction accuracy of SVM and 3D-QSAr models within 7% of actual performance.