Nanotechnology utilizes engineered materials and devices which function with biological systems at the molecular level and could transform the management of neurodegenerative diseases (NDs) by provoking, reacting to, and intermingling with target sites to stimulate physiological responses while minimizing side effects. Bloodbrain barrier (BBB) protects the brain from harmful agents, and transporting drugs across the BBB is a major challenge for diagnosis, targeting, and treatment of NDs. The BBB provides severe limitations for diagnosis and treatment of Alzheimer's disease (AD), Parkinson's disease (PD), and various other neurological diseases. Conventional drug delivery systems generally fail to cross the BBB, thus are inefficient in treatment. Although gradual development through research is ensuring the progress of nanotheranostic approaches from animal to human modeling, aspects of translational applicability and safety are a key concern. This demands a deep understanding of the interaction of body systems with nanomaterials. There are various plant-based nanobioactive compounds which are reported to have applicability in the diagnosis and treatment of these NDs. This review article provides an overview of applications of nanotheranostics in AD and PD. The review also discusses nano-enabled drug delivery systems and their current and potential applications for the treatment of various NDs.

In this study, near-field electrospinning (NFES) is used to fabricate Ba x Sr1 – x TiO 3 (BST)/poly(vinylidene fluoride) (PVDF) piezoelectric fiber composites with excellent mechanical properties and chemical properties. BST ceramic powder is blended with PVDF solution uniformly to prepare a solution of appropriate conductance. The parameter for BST/PVDF fiber processing is based on PVDF fibers. Scanning electron microscopy, differential scanning calorimetry, microtensile testing, Fourier transform infrared spectroscopy, and electricity test of the blends of BST/PVDF fibers are incorporated. Mechanical properties of the fibers are then measured by microtensile testing. Effects of distinct ratios of Ba/Sr and the content of Ba 0.7 Sr 0.3 TiO 3 ceramic powder on BST/PVDF piezoelectric fibers are discussed. Finally, BST/PVDF piezoelectric fiber composites are patterned on a poly(ethylene terephthalate) (PET)-based structure with an interdigital electrode as a BST/PVDF flexible energy harvester to capture ambient energy. The results show that the BST ceramic powder is ∼58–93 nm, and the diameters of piezoelectric fiber composites are ∼6.8–13.7 μm. The tensile strength of piezoelectric fiber composites is ∼74.92 MPa, and the Young’s coefficient tensile strength is ∼3.74 GPa. Mechanical properties are 2–3 times higher than those of pure PVDF piezoelectric fibers. The maximum open-circuit voltage and closed-loop current of BST/PVDF fibers reached ∼1025 mV and ∼391 nA, respectively. The electromechanical energy conversion efficiency of the BST/PVDF energy harvester is found to be 1–2 times higher than that of the PVDF energy harvester. It is confirmed and validated that the addition of BST ceramic powder could effectively increase the piezoelectric constant of PVDF piezoelectric fibers.