Objectives: This study was conducted to investigate alteration in blood parameters and their association with the presence, severity, and mortality of COVID-19 patients as the data on hematological abnormalities associated with the Pakistani COVID-19 patients is limited. Methodology: A double-centered, hospital-based comparative retrospective case study was conducted, to include all the admitted patients (n = 317) having COVID-19 Polymerase chain reaction (PCR) positive. The control group (n = 157) tested negative for COVID-19. Results: Of 317 admitted cases, the majority were males n = 198 (62.5%). Associated comorbidities, lower lymphocytes, platelets, and higher White blood cells, neutrophil, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were found in COVID-19 cases as compared to healthy controls (p < 0.001 for all). The biochemical parameters of cases including Ferritin, D-Dimer, CRP, IL-6, LDH, ALT, AST, and APTT also showed a statistically significant difference compared with standard values (p < 0.001 for all). However, their comparison with a severity level of the severe and non-severe groups showed significance for WBCs, neutrophils, NLR (p < 0.001 for all), and PLR (p = 0.06) only. Receiver operating characteristic curve analysis showed that NLR had the highest area under curve (0.84) followed by 1/lymphocyte (0.82), neutrophils (0.74), PLR (0.67),1/platelets (0.68) and WBC's (0.65). Comparison of cases and controls with recommended cut-off values derived from sensitivity and 1-specificity was also done (p < 0.001). Conclusion: Monitoring all the hematological and biochemical parameters including novel hemograms NLR, PLR can aid clinicians to identify potentially severe cases at early stages and initiate effective management in time which may reduce the overall mortality of COVID-19 patients.

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High angiogenesis and MCD predict poor survival and are positively correlated with each other and with the histological grades in pulmonary adenocarcinoma. High angiogenesis is also associated with advance TNM stage of disease.

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Objective: The purpose of this study is to observe the prevalence of depression, anxiety and stress among undergraduate MBBS students of Sahiwal Medical College Sahiwal stratified by their gender, class and residences. Study Design: Cross-sectional Survey. Setting: Sahiwal Medical College Sahiwal. Period: 15th March, 2020 to May 15, 2020. Material & Methods: A validated questionnaire was distributed through Whatsapp to different students of all the five MBBS classes. The online survey was done because of countrywide lockdown due to COVID-19 pandemic. Depression Anxiety and Stress Scale (DASS-42) accomplished by 209 students. Results: Depression, anxiety and stress levels of temperate to severe range were found in 48.30, 59.80 and 44.40% of our study group, respectively. Depression was more prevalent in male students (62.50%) while anxiety and stress totals were greater amongst female students (69.40% and 63.60% respectively). First- and final-year students had high prevalence of depression (71.00% and 72.40% respectively) and stress (64.50% and 72.40% respectively) while first year and 2nd year students were more prevalent with anxiety (77.40% and 79.60% respectively) then the others. Hostel residents were found to be high in depression (61.50%) while day scholars were having greater prevalence rates of anxiety and stress (70.40% each). Students who were pleased with their training had lesser depression, anxiety and stress scores than individuals who were not contented. Conclusions: The increased prevalence of depression, anxiety and stress signs amongst college students is disturbing. This displays the necessity for major and ancillary preventive actions, by the improvement of suitable and fitting support facilities for this group.