Resumo:O adequado e rápido atendimento de pacientes com situações clínicas ou cirúrgicas de urgência ou emergência é um dos principais focos das ações de Saúde Pública em nosso país e no mundo. É missão do meio acadêmico, portanto, desenvolver atividades para promover educação continuada sobre este tema. A despeito do ensino curricular nos cursos de graduação, ações extracurriculares, como as ligas, são importantes para ampliar este conhecimento, inclusive fora da universidade. O objetivo do presente artigo é relatar a experiência da Liga de Emergência da UFC (Universidade Federal do Ceará) -um projeto de extensão universitária -voltado para o tema de urgência/emergência e analisar seu impacto junto à sociedade. Para tanto, foram revisados os registros deste projeto de extensão, no sentido de identificar e analisar as atividades realizadas, os ambientes empregados para a execução das diversas ações e o público-alvo beneficiado por cada uma delas, desde sua criação até o final do ano de 2015. Observou-se que as diversas atividades de extensão realizadas ocorreram de forma articulada com ensino e pesquisa. Ao longo de 12 anos de existência, o projeto proporcionou a vivência em urgência/emergência para 74 acadêmicos e, em suas ações, já capacitou cerca de 6.000 pessoas. Projetos de extensão deste tipo cumprem papel importante de levar conhecimento qualificado para a comunidade, com alto potencial de transformar realidades.Palavras-chave: Ensino; Estudantes de Medicina; Emergências; Relações ComunidadeInstituição. Content shared under Creative Commons Attribution 3.0 Licence CC-BY
PURPOSE:To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS:Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosigmoidostomy (US) and treated with L-lysine, celecoxib and H 2 O, respectively. Groups D, E and F (non-operated controls) received L-lysine, celecoxib and H 2 O, respectively. The L-lysine dose was 150 mg/kg and that of celecoxib was 20 mg/kg. The colon was analyzed for the presence of aberrant crypt foci (ACF) under a stereomicroscope.The tissue was stained with hematoxylin and eosin and PAS alcian blue. RESULTS:There were rare ACF, and there was no statistically significant difference between the groups. Histopathologic study of the ureteral epithelium identified moderate to severe urothelial hyperplasia in rats with ureterosigmoidostomy. Transitional hyperplasia in the ureters of animals receiving L-lysine (A) showed an apparent difference compared to the control (C) (P=0.2424). There was no dysplasia or atypia.CONCLUSION: L-lysine does not promote carcinogenesis of the intestinal and urethelial epithelium of rats subjected to ureterosigmoidostomy at the doses and times studied.
Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L-lysine 1 5-Experimental SurgeryActa Cir Bras. 2017;32(3):297-306 Abstract Purpose: To evaluated the effects of L-lysine on the intestinal and urothelial epithelia in cystoplasty in rats. Methods: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) cystoplasty followed by administration of L-lysine (150 mg/kg body weight by gavage) for 30 weeks; Group B (n=8) cystoplasty + water for 30 weeks; Group C (n=6) L-lysine for 30 weeks; Group D (n=6) water for 30 weeks.Results: On histopathology with hematoxylin and eosin, mild to moderate hyperplasia transitional was observed in at the site of anastomosis in all animals submitted to cystoplasty (Groups A and B), but "transitional metaplasia" of the intestinal glandular epithelium was more accentuated in Group A (p=0.045). No inflammatory cells, dysplasia or abnormalities were observed. Staining with Alcian blue revealed a substantial reduction of goblet cells and mucins in the colon segment (Groups A and B). Conclusion:The administration of L-lysine to rats accelerated the development of transitional metaplasia in the epithelium of the colon segment in cystoplasty.
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