Our 42-year-old patient had comedonal Darier's disease (DD) on the face, comedonal cornifying DD on the upper back, and hypertrophic DD on both legs. Biopsies taken from face, upper back and medial sides of the legs were found to be compatible with these clinical subtypes. The comedonal type was in the classical place, but the hypertrophic and cornifying types were not in the usual sites. In addition to the classic histopathology of DD, we noted multiple, warty dyskeratoma-like structures in the comedonal type, marked compact hyperkeratosis in the cornifying type, and marked papillomatosis in the hypertrophic type.
Autoimmune polyglandular syndrome (APS) is a rarely diagnosed condition characterized by a combination of two or more organ-specific autoimmune diseases and divided into a very rare juvenile (APS type I) and a relatively common adult type (APS II-IV). The major components of APS-I are hypoparathyroidism, adrenal failure, and mucocutaneous candidiasis. In addition to the classic triad, many other autoimmune diseases could be associated with the syndrome. We report an adolescent patient with psoriasis vulgaris and APS-I.
ÖzBackground and Design: The aim of this study was to determine the frequency of dermatological infections among Turkish wrestlers. Materials and Methods: We included 202 wrestlers from different regions of Turkey who volunteered to participate in the study. The "Athlete Biography and Dermatologic Examination Findings" survey that was designed before the research was completed during dermatological examination and dermatologic findings of each athlete were evaluated. Results: During the physical examination of 202 Turkish wrestlers, 115 (57%) of participants were observed to have skin infection while no skin infection was found in 87 (43%). It has been detected that these infections were fungal, bacterial and viral in 31%, 18% and 8% of patients, respectively. The rates of infections were 25
A 20-year-old man presented to our clinic with progressive and asymptomatic mottled hyperpigmentation involving almost the whole of his body, which had been present since he was 8 years of age. The first lesions had appeared on the trunk and hyperpigmentation had extended gradually over the years to involve the neck, face and limbs. He had also noticed spotty hypopigmentation among the hyperpigmented macules.He did not have any inflammatory skin disease or systemic illness prior to the onset of the lesions. He reported similar skin changes in his father, sister and two brothers. Only one of his brothers was free of any lesions.On physical examination, areas of mottled hyperpigmentation and hypopigmentation with macules of varying sizes, ranging from 2 to 15 mm, were seen, involving almost the whole of the body (Fig. 1) in a symmetrical pattern with relative sparing of the hands and feet. Hair, nails, teeth, palms, soles and oral mucosae were normal. Systemic examination was unremarkable and routine blood investigations were normal.
Histopathological findingsHistopathological examination of a skin biopsy from a pigmented macule revealed melanin incontinence. The number of melanocytes was normal. There was no collagen abnormality (Fig. 2).What is your diagnosis? C P D
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