Background: Problems that arise in COVID-19 patients include, often experiencing deep anxiety characterized by fear of pain, fear of death, fear of losing personal independence, fear of losing role functions that can cause physiological changes, namely a decrease in Oxygen Saturation (SaO2). Methods: The design of this study was a quasi-experimental approach with a Pretest-Posttest Control Group Design approach. The population of all COVID-19 patients at the Surabaya A. Yani Islamic Hospital is 187 people. The sample size is 34 respondents according to the established criteria with purposive sampling technique. The intervention group was given Spiritual Deep Breathing Exercise for 15-20 minutes and the control group was given an intervention according to hospital standards for 1 week. Analysis on anxiety used the Wilcoxon Signed Rank Test and mann whitney test. The Oxygen Saturation (SaO2) used paired sample T test and independent sample T test. Results: The results of the Anxiety analysis in the intervention group obtained a p value of 0.000 and a p value of 0.197 in the control group. The results of the Oxygen Saturation (SaO2) analysis in the intervention group obtained a p value of 0.000 and in the control group a p value of 0.884. The results of the analysis on anxiety p value 0.000 and Oxygen Saturation (SaO2) value p value 0.003 between the intervention group and the control group which means there is a difference in anxiety and Oxygen Saturation (SaO2) between the intervention group and the control group. control group in COVID-19 patients. Conclusion: Spiritual Deep Breathing Exercise theory is effective in reducing anxiety and stabilizing the value of Oxygen Saturation (SaO2) in COVID-19 patients, and this technique is easy to do, so it can be applied as a nursing intervention in isolation rooms for the development of nursing science in hospitals.

Complications experienced by DM patients will affect the patient's quality of life. Efforts that can be done to maintain the quality of life, one of which is by lifestyle management. This training is expected to increase the knowledge and skills of health cadres in teaching lifestyle management to improve the quality of life of people with diabetes mellitus. The method used in this community service activity is to provide health counseling. This activity was carried out for one month and was attended by 15 cadres and 50 people with DM. Quality of life is measured by DQOL (Diabetes Quality of Life). After one month of service, it was found that 98% of the quality of life of people with DM increased (good). Lifestyle management can maintain the quality of life of people with DM through maintaining stable blood sugar levels

Background: Covid-19 has infected a lot of people in various countries. The implementation of vaccination raises new problems in the public, there are positive and negative reactions regarding the vaccination program. Incorrect data regarding the Covid-19 vaccine causes anxiety, fear and doubt.Objective: The purpose of this study was to determine the relationship between family support and motivation to participate in Covid-19 vaccination among members of Tentara Nasional Indonesia (TNI) Angkatan laut (AL) in the Kodiklatal Satkes area.Method: This research used a correlational analytic design with a cross sectional approach. The population in this research is all members of the Tentara Nasional Indonesia (TNI) Angkatan laut (AL) with the rank of enlisted in the Kodiklatal Satkes area as many as 384 people. The sample is 196 respondents using simple random sampling. The independent variable is family support and the dependent variable is motivation to participate in the Covid-19 vaccination.Results: The results showed that of the 196 respondents, most (58.7%) had good family support and most (52.8%) had high motivation. Based on the Spearman rank test, p value = 0.000 (p <0.05) which means that there is a significant relationship between family support and motivation to participate in the Covid-19 vaccination for members of the Tentara Nasional Indonesia (TNI) Angkatan laut (AL) with the rank of enlisted in the Kodiklatal Satkes area.Conclusion: The better the family support, the higher the motivation of a person in participating in the implementation of vaccination. It is hoped that regular guidance from health facilities and health workers can increase one's motivation in participating in the implementation of the Covid-19 vaccination.

Measurement of the level of von Willebrand factor antigen (VWF:Ag) in human plasma is usually carried out in a specialized laboratory in routine clinical practice and is carried out by the ELISA method which takes a long time or immunoturbidimetry which is less sensitive and specific. The purpose of this study was to qualitatively determine the von Willebrand factor (VWF) antigen in only a maximum of 5 min using the latex agglutination method. The research design is an exploratory laboratory experiment. This study was conducted in a cross sectional manner in patients with bleeding disorders with prolonged bleeding time and healthy individuals. The research stage is to prepare a VWF polyclonal antibody from Invitrogen Ref. Pa5-16634 with Lot No. XE3587846A in 0.1M MES{2-(N-morpholino) ethane-sulfonic acid buffer, 0.9% sodium chloride, pH 6, to be sensitized to Carboxyl latex, 4% w/v 1 m. Latex particles after passive adsorption, polyclonal antibodies stick to the latex surface. The patient's citrate blood sample is taken which will be compared with the normal individual's citrate blood. The results showed agglutination in patients with bleeding disorders and no agglutination in normal individuals. In conclusion, latex reagent containing polyclonal VWF can be used as a diagnostic tool to determine VWF antigen in patients with bleeding disorders.