The study developed two models of an innovative high-speed lancing device and safety lancet, where the specially designed structure causes high-speed motion of the lancet, resulting in only one puncture of the skin. The two experimental models and other lancing devices sold on market were compared in order to: (1) measure the forces of lancets piercing animal skin by a load cell; (2) observe the wound areas caused by lancing devices under a microscope. The experimental results showed that, after using this innovative high-speed lancing device, the maximum force of a lancet piercing skin is only 1/3 of the force of conventional lancing devices, and the duration of the former under the skin is 1/6 of the latter. In addition, the wound area caused by the innovative lancing device is 20 % smaller than those of the conventional lancing devices. Usage of this innovative high-speed safety lancet shows that its maximum skin-piercing force is only 2/3 of conventional safety lancets, its duration under the skin is 1/4 of conventional safety lancets, and the wound area is 12 % smaller. In conclusion, both the innovative high-speed lancing device and safety lancet are proved effective in alleviating pain for diabetics and shortening the recovering time for wounds, thus, providing a more comfortable process for the self-monitoring of blood glucose.

This paper reviews the practical process of designing the electrodes on electroless immersion gold-plated test strips for glucose measurement. We have found that great care must be taken on determining the width and length of the working and reference electrodes, to yield the optimum performance on electroless immersion gold-plated glucose test strips for glucose measurement. Preferably, a width of at least 0.6 mm and a length of at least 24 mm are recommended to prevent variance in electrode resistance during mass production of electroless immersion gold-plated glucose test strips, in order to enhance the accuracy of glucose measurement. This paper also recommended that, if two different geometric sizes of test strips are going to be used on the same glucose meter, both test strips must use different lengths and widths on the working and reference electrodes to yield the same electrical resistance and hence similar electrochemical performance.

An innovative high-speed lancing device has a lancet that moves so fast that it is not affected at all by the vibration of its spring, and does not pierce the skin repeatedly, greatly reducing the pain that is caused to diabetes mellitus (DM) patients during blood sampling. As revealed by experimental measurements of the acceleration of a lancet using an accelerometer, the lancet pierces the skin only once. The maximum acceleration and the instant piercing velocity of the lancet are 9.4 times and 1.78 times those of a conventional lancing device, respectively. Meanwhile, the period for which the lancet remains in the skin is 0.014 s shorter than that of the conventional lancing device. A clinical trial that involved 100 participants yielded statistical results concerning the numeric rating of pain scale (NRS) of pain intensity, which is internationally recognized as the pain with the highest validity, that showed that the NRS of participants who used the innovative high-speed lancing device was 2.65 less than that of those who used the conventional lancing device, and the duration of the pain after blood sampling was 76.1 min shorter.

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