The study reports the phenolic composition of propolis from Bangladesh and its ameliorative effects against tetracycline‐induced hepatonephrotoxicity in rats. Male Wistar Albino rats (n = 18) were randomly divided into three following groups: (1) normal control, (2) tetracycline‐treatment (200 mg kg−1 rat−1), and (3) tetracycline (200 mg kg−1 rat−1) + propolis (100 mg kg−1 rat−1) treatments. The ethanolic extract of propolis contained major phenolic acids as well as a flavonoid, rutin. Oral exposure to tetracycline caused severe hepatic and renal damage as indicated by significant alterations in liver marker enzymes in rat serum: bilirubin and protein concentrations, lipid profile, and markers of kidney function when compared with controls. The observed biochemical perturbations were accompanied by histopathological changes. Co‐administration with propolis extract, however, prevented the changes in biochemical parameters, as revealed by maintenance of cell membrane integrity and regulation of lipid profile and the conservation of the histoarchitecture. Practical applications Propolis is a resinous honeybee product which is becoming increasingly popular due to its potential contributions to human health. The phenolic compounds identified in propolis from Bangladesh were effective against tetracycline‐induced hepatic and renal toxicity. Propolis may be a promising natural product in reducing the effects of chronic liver and kidney damage.

The objective of the study was to investigate Limonia acidissima L. (wood apple) to determine the moisture and ash content, total amount of carbohydrates, fatty acid compositions, the quantity of protein and micronutrients (Na, K, Zn, Fe) present in wood apple grown in Bangladesh. FT-IR spectroscopy was used to pinpoint many biologically significant functional groups. The moisture and ash content obtained were 74.02 and 25.44%, respectively. Carbohydrate content determined by ultraviolet-visible (UV-Visible) spectroscopic method was 16.14 g per 100 g of dried fruit sample. The fatty acids were identified by Gas Chromatography-Flame Ionization Detector (GC-FID). The relative percentage of bound fatty acids mainly palmitoleic acid, octadecanoic acid, cis-9-oleic acid and octanoic acid were 17.33, 15.09, 15.09 and 45.09%, respectively. The amount of protein was 5.11%. The micronutrients such as Na, K, Zn, Fe present in the edible portion of wood apple measured by atomic absorption spectroscopy (AAS) were 10.40, 58.24, 0.37 and 1.67 mg per 100 g of dried sample, respectively. The fruit has long been utilized in herbal medicines and is eaten raw or processed into various products to prevent noncommunicable diseases and micronutrient deficiencies. Dhaka Univ. J. Sci. 70(2): 48-52, 2022 (July)