Inhibition of advanced glycation end products (AGEs) and free radicals generated during diabetes represents a major therapeutic target in the prevention and treatment of diabetic complications. Natural molecules present in fruits, vegetables and herbs and which are usually safe for human consumption, could represent a strong glycation inhibitor. Anti-glycation effect of nine plant species used in traditional medicine has been evaluated after extraction by hot (EAC) or cold (EAF) maceration and by ethanol (EE). Anti-glycation activity performed on a model system of bovine serum albumin, and methylglyoxal was measured by fluorescence and native electrophoresis. Total phenolic and flavonoid contents were assessed as well. Except for Sesamum indicum, all the species studied have an Anti-glycation effect. The highest effect was recorded in Laurus nobilis and was dose-dependent, inhibiting both formations of Amadori products and fluorescent AGEs. HPLC analysis revealed a richness of Laurus nobilis EE in phenolic compounds such as quercetin, vanillin and gallic acid. A strong correlation was registered between antioxidant power and phenolic/flavonoid content. In contrast, there was no correlation between antioxidant and anti-glycation power. Phenolic and flavonoid compounds were strongly involved in the observed anti-glycation effect. However, the anti-glycation activity obtained is probably attributed to non-antioxidant compounds.

Organic household waste has a high organic content (69 g/kg), value of pH equal to 6,3 with 94% of moisture. Anaerobic digestion is one of the technologies for recycling and stabilization of organic waste, the process is carried out in 3L reactor at semi continuous and mesophelic conditions. During the anaerobic digestion of OHW, pH was around neutrality (between 6,5 and 8), a decrease of alkalinity was observed reaching a value of 900 mg CaCo 3 /L), total and volatile solid were accumulated at the end of the experiment. Result of biogas production indicates that a higher methane yield was obtained for the load 0,5 g VS/L, methanogenic potential for the anaerobic digestion of OHW was 0,15L STP /g VS.

Toxicovigilance is the active process of identifying and evaluating the toxic risks existing in a community, and evaluating the measures taken to reduce or eliminate them. The operation of toxicovigilance requires the use of methods, tools, and techniques. The objective of this article is to describe the organization of toxicovigilance, to identify their components, and to specify the methods, tools and techniques which are applied to them and are necessary for their operation. To achieve those goals, we based our study on a bibliographic synthesis, where some key references were selected, analysed, and summarised. The results of our study have shown that the performance of a toxicovigilance system requires the mastery and integration of methods, tools, and techniques by trained and experienced staff. Those methods, tools and techniques can be classified into six stages. The study also showed that the practice of toxicovigilance is one of the core tasks of a poison control centres. Our study has shown that Anti-poison and Pharmacovigilance center Morocco constitutes a real observatory in terms of toxicovigilance. It ensures a vigilance and alert function concerning different toxic groups.