Background: DM is a metabolic condition caused by deficiencies in insulin synthesis, insulin action, or both. It is characterised by chronic hyperglycemia and glycosuria, as well as abnormalities in carbohydrate, fat, and protein metabolism. Diabetes and its complications are believed to be caused by a variety of causes. Genetics, diet, sedentary lifestyle, perinatal causes, age, and obesity are among them.  The relationship and interaction of various risk factors with disease severity is still unknown, so the aim of the proposed study was to determine the possible relationship between biochemical markers glycosylated haemoglobin, lipid profile, insulin resistance, and immunological markers TNF- and IL-6, in order to suggest appropriate measures to reduce the country's diabetes burden. Materials and Methods: A total of 300 people were chosen for the study after visiting Shalinitai Meghe hospital in Nagpur for a health check-up. The three groups were contained in this area. Results: Both biochemical and immunological parameters rose in managed diabetic patients and significantly increased in uncontrolled diabetic patients, according to the report, but values did not differ between groups 1. Conclusion: Low-grade inflammation and inflammatory mediator upregulation have been suggested to play a role in T2DM etiology. TNF- and IL-6 have a positive connection with T2DM and insulin sensitivity, according to our data. These can be used as T2DM biomarkers in the early stages of the disease. To help doctors monitor and treat T2DM successfully, more research on a larger spectrum of pro and anti-inflammatory cytokines (mediators) in conjunction with other biochemical, immunoassay, and hematological markers is needed.

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