Inherent distortions affect the spatial geometry of optical coherence tomography (OCT) images and consequently the foveal pit dimensions. Distortion correction provides an accurate anatomical representation of the retinal shape. A novel approach that automatically extracts foveal pit metrics from distortion-corrected OCT images using a sum of Gaussian function is presented. Foveal width, depth and slope were determined in 292 eyes with low fitting errors and high repeatability. Comparisons to undistorted scans revealed significant differences. To conclude, the internal OCT distortions affect the measurements of the foveal pit with their correction providing further insights into the role of foveal morphology in retinal pathologies and refractive development.

Presbyopia is an age-related loss of accommodation ability of the eye which affects individuals in their late 40s or early 50s. Presbyopia reduces the ability of a person to focus on closer objects at will. In this study, we assessed electronically tunable lenses for their aberration properties as well as for their use as correction lenses. The tunable lenses were evaluated in healthy subjects with cycloplegia by measuring visual acuity and contrast sensitivity for their use in presbyopia correction. Furthermore, we have developed and demonstrated the feasibility of a feedback mechanism for the operation of tunable lenses using a portable solid-state LIDAR camera with a processing time of 40 ± 5 ms.

Eccentric photorefraction is an objective technique to determine the refractive errors of the eye. To address the rise in prevalence of visual impairment, especially in rural areas, a minicomputer-based low-cost infrared photorefractor was developed using off-the-shelf hardware components. Clinical validation revealed that the developed infrared photorefractor demonstrated a linear working range between +4.0 D and −6.0 D at 50 cm. Further, measurement of astigmatism from human eye showed absolute error for cylinder of 0.3 D and high correlation for axis assessment. To conclude, feasibility was shown for a low-cost, portable and low-power driven stand-alone device to objectively determine refractive errors, showing potential for screening applications. The developed photorefractor creates a new avenue for telemedicine for ophthalmic measurements.

When considering external assistive systems for people with motor impairments, gaze has been shown to be a powerful tool as it is anticipatory to motor actions and is promising for understanding intentions of an individual even before the action. Up until now, the vast majority of studies investigating the coordinated eye and hand movement in a grasping task focused on single objects manipulation without placing them in a meaningful scene. Very little is known about the impact of the scene context on how we manipulate objects in an interactive task. In the present study, it was investigated how the scene context affects human object manipulation in a pick-and-place task in a realistic scenario implemented in VR. During the experiment, participants were instructed to find the target object in a room, pick it up, and transport it to a predefined final location. Thereafter, the impact of the scene context on different stages of the task was examined using head and hand movement, as well as eye tracking. As the main result, the scene context had a significant effect on the search and transport phases, but not on the reach phase of the task. The present work provides insights into the development of potential supporting intention predicting systems, revealing the dynamics of the pick-and-place task behavior once it is realized in a realistic context-rich scenario.