Since immemorial herbal plants were widely used as medicine for the treatment of inflammatory disorders. Much focus has been attributed for the importance of medicinal plants by WHO. Present study aims at investigating the anti-inflammatory activity of aqueous and methanol extract of Convolvulus arevensis which is indigenous to Eastern Ghats of Andhra Pradesh. Materials and methods: Leaves of C.arvensis was subjected to aqueous and methanol extraction by soxhlet and assessed for in-vitro anti-inflammatory activity by albumin denaturation inhibition and membrane stabilization method. Results: Percentage yield for aqueous extract of C.arvensis (ACAE)was found to be (89%) and for methanol extract(MCAE) it was found to be (92%).Significant dose dependent in-vitro anti-inflammatory activity (50-150µg) was observed(p<0.05) for both ACAE and MCAE. Percentage of albumin denaturation for MCAE 150µg was found to be 77.65% (IC50 =38.40µg; R2 = 0.9610) and for that of ACAE it was found to be 69.073%. (IC50 =42.28µg; R2 =0.9880) for albumin denaturation. Percentage of protection for MCAE 150µg was found to be 71.77% (IC50 =38.40µg; R2 = 0.9610) and for that of ACAE it was found to be 71.93%. (IC50 =32.52µg; R2 = 0.9975).

Congenital Hydrocephalus is due to buildup of excess cerebrospinal fluid in the brain at birth. Fluid buildup leads to neurological and psychological damages to the child. Aqueductal stenosis means a narrowing the passageway between the third and fourth ventricles. In this case report, Ventriculoperitoneal shunt is placed to relieve the pressure, but was removed due to Meningitis. As per review of literature, incidence of shunt failure in infants below 2 years is 5-12% and with more than 60% mortality rate.

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Plants are the major source of human living. Since the beginning of the era, plants have been used for medicinal purposes. There is dire to explore the mechanism of chemical constituents in plants and particularly saponins, cardiac glycosides, and flavonoids due to their mechanism to save damaged cells in cardiac muscle. Databases like Google Scholar, Medline, PubMed, and the Directory of Open Access Journals were searched to find the articles describing the cardioprotective mechanism of medicinal plants. Saponin, flavonoids, glycoside, steroid, alkaloids, tannin, phenol, phlorotannin, terpenoids, and anthraquinone are chemical constituents in plants that enhance cardioprotection activity and decreases cardiac abnormalities. The current review article provides data on the use of medicinal plants, specifically against cardiac diseases, as well as an investigation of molecules/phytoconstituents as plant secondary metabolites for their cardioprotective potential.

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