Since immemorial herbal plants were widely used as medicine for the treatment of inflammatory disorders. Much focus has been attributed for the importance of medicinal plants by WHO. Present study aims at investigating the anti-inflammatory activity of aqueous and methanol extract of Convolvulus arevensis which is indigenous to Eastern Ghats of Andhra Pradesh. Materials and methods: Leaves of C.arvensis was subjected to aqueous and methanol extraction by soxhlet and assessed for in-vitro anti-inflammatory activity by albumin denaturation inhibition and membrane stabilization method. Results: Percentage yield for aqueous extract of C.arvensis (ACAE)was found to be (89%) and for methanol extract(MCAE) it was found to be (92%).Significant dose dependent in-vitro anti-inflammatory activity (50-150µg) was observed(p<0.05) for both ACAE and MCAE. Percentage of albumin denaturation for MCAE 150µg was found to be 77.65% (IC50 =38.40µg; R2 = 0.9610) and for that of ACAE it was found to be 69.073%. (IC50 =42.28µg; R2 =0.9880) for albumin denaturation. Percentage of protection for MCAE 150µg was found to be 71.77% (IC50 =38.40µg; R2 = 0.9610) and for that of ACAE it was found to be 71.93%. (IC50 =32.52µg; R2 = 0.9975).