No abstract

Background: Migraine is a Primary Headache disorder, the exact aetiology of which till date is not established. Various neuroinflammatory conditions, cytokines, oxidative stress, neuropeptides and vasomotor changes have been hypothesized for the pathogenesis of migraine headache. Aim and Objective: The aim of this study was to evaluate inflammatory and non-inflammatory marker levels in patients with migraine and compare with levels measured in controls. Materials and Methods: This is a case control study of 45 cases of migraine between age group 15-50 years of either sex attending the outpatient department (OPD) of E.N.T, VIMSAR Burla between July 2019 to December 2019.After proper history and clinical evaluations, we analysed the serum level of inflammatory markers like Neutrophil-to-lymphocyte ratio (NLR), Malondialdehyde (MDA), C-Reactive Protein (CRP) and anti-inflammatory marker Adiponectin in migraine patients. We compared blood levels of these parameters of migraine patients with 45 controls attending the same OPD for ENT diseases other than migraine during the same period. Results: The Unpaired t test between case and control groups shows significant increase in serum level of NLR,MDA and CRP in migraine patients compared to controls(P≤0.05).The case and control group did not show a significant difference in the value of adiponectin. Conclusion: This study indicates that oxidative stress marker(MDA) and inflammatory markers like NLR and CRP may be potential risk factor for migraine. So, early prediction of inflammatory markers might be beneficial in management of migraine patients.

Background: Since the outbreak of global pandemic, wearing face mask not only protects the individual but also limits the spread of corona virus infection in the community. However, certain sociocultural and personal factors have created hinderance in wearing face mask by general people against COVID-19 virus. Aims and Objectives: The aim and objective of this study is to assess the knowledge, intension, and practice of wearing face mask among common people. Materials and Methods: It was a cross-sectional study conducted among general people in a part of Western Odisha after ethical approval. A total of 1050 adults above 18 years participated in this study. The data were collected from different locality of the town using a pretested self-administered questionnaire by all authors and research assistants of this project. The period of study was from July 2021 to December 2021. The results were tabulated, processed, and analyzed using SPSS-20. Results: Regarding knowledge score, we observed that 57% had average, 18% had poor, and 25% had good knowledge. Furthermore, we found 42% participants had positive intention and 58% had negative intention. Again we assessed that 35% of participants were practicing face mask appropriately and 65% practicing inappropriately. Conclusion: In this study, the score of knowledge, intention, and also the practice of wearing face mask against COVID-19 was lower than the average as compared to previous researches. Hence, health authorities should promote the people to wear mask and encourage awareness programs for the benefit of the society.

Background: Migraine is a Primary Headache disorder, the exact aetiology of which till date is not established. Various neuroinflammatory conditions, cytokines, oxidative stress, neuropeptides and vasomotor changes have been hypothesized for the pathogenesis of migraine headache. Aim and Objective: The aim of this study was to evaluate inflammatory and non-inflammatory marker levels in patients with migraine and compare with levels measured in controls. Materials and Methods: This is a case control study of 45 cases of migraine between age group 15-50 years of either sex attending the outpatient department of Otorhinolaryngology, Veer Surendra Sai Institute of Medical Sciences and Research, Burla between July 2019 to December 2019. After proper history and clinical evaluations, we analysed the serum level of inflammatory markers like Neutrophil-to-lymphocyte ratio, Malondialdehyde, C-Reactive Protein and anti-inflammatory marker Adiponectin in migraine patients. We compared blood levels of these parameters of migraine patients with 45 controls attending the same outpatient department for diseases other than migraine during the same period. Results: The Unpaired t test between case and control groups shows significant increase in serum level of Neutrophil-to-lymphocyte ratio, Malondialdehyde, C-Reactive Protein in migraine patients compared to controls. The case and control group did not show a significant difference in the value of adiponectin. Conclusion: This study indicates that oxidative stress marker (Malondialdehyde) and inflammatory markers like Neutrophil-to-lymphocyte ratio and C-Reactive Protein may be potential risk factor for migraine. So, early prediction of inflammatory markers might be beneficial in management of migraine patients.

No abstract