Indian phenotype having greater abdominal adiposity, higher waist circumference (WC) & lower body mass index (BMI), thereby making the indians more prone to diabetes and it's complications. Type-2 diabetes mellitus (T2DM) worldwide known for its morbidity and mortality. Recent studies have demonstrated that the abnormal levels of adipocytokines (Adiponectin, leptin) may contribute to Insulin resistance (IR) and T2DM. Aim: The present study aimed to analyze circulatory levels of Adiponectin & Leptin with Insulin Resistance in study subjects compared with control subject & Type-2 diabetes mellitus (T2DM). Materials and Methods: A total 120 T2DM patients and 120 healthy subjects aged between 30 and 60 years who were Non-diabetic, Non-hypertensive and having no family history of hypertension visiting to Medicine OPD were included in study. Parameters such as age, sex, anthropometric measures and biochemical indicators like fasting and postprandial blood sugar, lipid profile, adiponectin, leptin, fasting insulin, HOMA-IR & systolic and diastolic blood pressure were determined & compared with control subjects. Result: Adiponectin levels were reported significantly lower in T2DM group whereas Leptin levels were significantly higher in T2DM group compared to non-diabetics group (P ≤ 0.001) in both genders. Conclusion: Adiponectin & Leptin levels are used as an important clinical biomarkers for T2DM and obesity. IR, Adiponectin and Leptin can be used as cut off to predict the occurrence of T2DM.